Thyronine - Liothyronine

Pyridinol carbamate 160 ,170 -Dihyd roxy progesterone Algestone acetophenide L-Diiodo thyronine Liothyronine p-Diisobutylphenol... 

The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure L-triiodo thyronine has MP 236° to 237°C (dec.) and [a]D29-5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCI and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt. 

L-thyroxine (T j or tetraiodo-L-thyronine) and liothyronine (Tg or triiodo-L-thyronine) are the natural hormones of the thyroid gland. is a less active precursor of Tj, which is the major mediator of physiological effect. In this chapter for therapeutic use is referred to as levothyroxine (the rINN, see p. 83) rather than levothyroxine (the former usage). 

Liothyronine, 0-(4-Hydroxy-3 iodophenyl)-3,5-diiodo-L-tyrosine L-3-[4-(4-hydroxy-3-iodophertoxy)-3,5-diiodophenyljalanine 4 -(3 -iodo -4 -hydroxyphenoxy) -3,5 -diiodophenylalanine 3,5,3 -triiodothyronine T-3 Triothy-rone. C HyljNO mol wt 651.01. C 27 68%, H 1.86%, I 58.48%, N 2.15%, O 9.33%, Amino acid found in human plasma and thyroid gland, similar to thyroxine q-v. Gross, Pitt-Rivers, Lancet 1952, I, 439. Formation from diiodo-thyronine Roche et al., Biockem. Blophys. Acta 11, 215... 

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