Liothyronine

Sodium Liothyronine. Sodium hothyroniae [55-06-1] is the sodium salt of L-3,5,3 -triiodothyroniQe. It is made by the controlled iodiaation of L-3,5-diiodothyronine. It may be contaminated by starting material or l-T. The USP assay (49) describes a chromatographic separation specifying 3,5-T2... 

Pyridinol carbamate 160 ,170 -Dihyd roxy progesterone Algestone acetophenide L-Diiodo thyronine Liothyronine p-Diisobutylphenol... 

Liothyronine (T3) 25-50 meg IV bolus. Use 10-20 meg IV bolus in patients with CAD. Subsequent doses (e.g., 2.5-10 meg IV q6-8h) should be administered between 4—12 h after the initial bolus dose and continued until signs and symptoms resolve... 

Liothyronine (Cytomel ) SyntheticT3 5, 25, and 50 meg tablets 15 meg Rarely needed in treatment of hypothyroidism rapid absorption and pharmacologic effect increased toxicity versus LT4 no outcome benefit to combining with LT4... 

MISCELLANEOUS ARYLALKANOIC ACIDS It has been known for some time that thyroxine, and related compounds such as liothyronine (88) are effective in lowering serum cholesterol. The normal metabolic activity of this class of thyroid active compounds has precluded their use as hypocholesterol-emic agents. 

Liothyronine (synthetic T3) has uniform potency but has a higher incidence of cardiac adverse effects, higher cost, and difficulty in monitoring with conventional laboratory tests. 

Immediate and aggressive therapy with IV bolus levothyroxine, 300 to 500 meg, has traditionally been used. Initial treatment with IV liothyronine or a combination of both hormones has also been advocated because of impaired conversion of T4 to T3. 

Leffler Freytag reaction, 338 Leprosy, 139 Levallorphan, 293 Levarteronol, 63 Levolorphanol, 296 Levonordefrine, 68 Levophenacylmorphan, 294 Levopropoxyphene, 50 Levorphanol, 293 Levothyroxine, 97 Librium , 365 Lidocaine, 16 Lidoflazine, 279 Liothyronine, 97 Lipid-water partition, 3, 21 Lipophilicity, 213 Lorazepam, 368 Lucanthone, 397 Lumisterol, 184 Lyndiol , 186... 

Levothyroxine is used to treat hypothyroidism (an underactive thyroid gland). Thyroid hormone can be made from beef and pork thyroid, but this lacks standardization and it is difficult to control dosage. The synthetic drug is more desirable. Levothyroxine is one of two important thyroid hormones. It is converted into the second important hormone, liothyronine, in the body. The key step in the synthesis of structures such as levothyroxine is the substitution of an iodonium salt by an iodinated phenol. Siql-like reactions on an aromatic ring are not common, but an iodonium salt provides a good leaving group. 

Pituitary TSH suppressants In the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute, or chronic lymphocytic thyroiditis (Hashimoto), multinodular goiter, and in the management of thyroid cancer (except liothyronine). 

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