Thyroid suppression therapy, euthyroid

Thyroid suppression therapy of euthyroid goiter (B). The cause of goiter (struma) is usually a dietary deficiency of iodine. Due to an increased TSH action, the thyroid is activated to raise utilization of the little iodine avail-Liillmann, Color Atlas of Pharmacology 2000 Thieme All rights reserved. Usage subject to terms and conditions of iicense. 

Levothyroxine is indicated in the treatment of hypothyroidism (0.05 mg initially) of myxedema coma (0.4 mg IV initially) of thyroid-stimulating hormone (TSH) suppression in thyroid cancer of euthyroid and nodules goiter and of thyroid suppression therapy (2.6 mcg/kg/day for 7 to 10 days). Levothyroxine increases the metabolic rate of tissue. It affects protein and carbohydrate metabolism, promotes gluconeogenesis, increases the utilization and mobilization of glycogen stores, stimulates protein synthesis, and regulates cell growth and differentiation. The orally administered... 

Nervous system Iatrogenic subclinical hyperthyroidism is induced in patients with differentiated thyroid cancer in order to reduce the risk of recurrence. Long-term exogenous subchnical hyperthyroidism causes autonomic nervous system abnormalities, and lower heart rate variability and increased urinary catecholamine excretion are common. After restoration of euthyroidism for a minimum of 6 months in 12 patients who underwent TSH suppressive therapy for more than 10 years, autonomic nervous system abnormalities... 

Liothyronine sodium is a thyroid hormone that increases metabolic rate of body tissues and is needed for normal growth and maturation. It is indicated for the replacement or supplemental therapy in hypothyroidism in TSH suppression for treatment or prevention of euthyroid goiters (e.g., thyroid nodules, multinodular goiters, enlargement in chronic thyroiditis) and as a diagnostic agent in suppression tests to differentiate suspected hyperthyroidism from euthyroidism and in treatment of myxedema coma/precoma (IV). 

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