Thyroid hormones cholinergic neurones

THYROID HORMONES AND NEUROTRANSMITTER SYSTEMS AN INTERACTION WITH NERVE GROWTH FACTOR IN THE REGULATION OF CHOLINERGIC NEURONES... [Pg.139]

INTERACTION BETWEEN THE EFFECTS OF THYROID HORMONE AND NERVE GROWTH FACTOR (NGF) ON CHOLINERGIC NEURONES... [Pg.141]

The elevation of ChAT activity is due to an increase in the amount of enzyme per cholinergic cell, since neither treatment with NGF nor with thyroid hormone has a significant effect on the number of cells in the cultures, including the cholinergic neurones, When cultures are supplemented with both agents at maximal effective concentrations, the stimulation in ChAT activity is much greater than the sum of the individual effects (Fig, 2). [Pg.143]

Interaction between the effects of thyroid hormone and NGF on ChAT activity. Neuronal cultures enriched in cholinergic cells were grown for 10 days in either normal chemically defined medium or the same containing different concentrations of either 3,3 ,5-triiodo-L-thyronine (T3) or NGF or both agents. Results are expressed as a percentage of control ChAT activity. Each column is the mean value with S.E.M. indicated by the bar. The data are taken from Hayashi and Patel.8... [Pg.143]

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