Thromboxane endotoxin effect

At this time, it is difficult to reconcile the results from all the studies in the literature regarding the role of specific eicosanoids or PAF in the development of endotoxin-induced lung injury. The differences in results may be due to the use of inadequate or ineffective inhibitors, different doses and preparation of endotoxin, variable sensitivity of different species of animals to endotoxin effect and differences in eicosanoid metabolism in different species . A final possibility is that perhaps none of the metabolites alone is adequate to cause injury, but mediator chain reactions and synergistic actions of several mediators are important. This might explain why interventions targeting a single mediator (thromboxane or leukotrienes) have so far met with limited success. 

Ogletree, M.L., Hutchison, A.A., Snapper, J.R. and Brigham, K.L. (1982). Effects of alveolar hypoxia and endotoxin on lung lymph prostacyclin and thromboxane metabolites in unanesthetized sheep. Fed. Proc., 41, 1686... 

Cook, J.A., Wise, W.C. and Halushka, P.V. (1980). Elevated thromboxane levels in the rat during endotoxin shock Protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. ]. Clin. Invest., 65, 227-230... 

Watkins, W.D., Huttemeier, P.C., Kong, D. and Peterson, M.B. (1982). Thromboxane and pulmonary hypertension following . coli endotoxin infusion in sheep Effect of an imidazole derivative. Prostaglandins, 23, 273-285... 

Ball, H.A., Parratt, J.R. and Zeitlin, I.J. (1983). Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary response to E. coli endotoxin in anesthetized cat. Br. ]. Clin. Pharmacol, 15, 1275-1315... 

Kubo, K. and Kobayashi, T. (1985). Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. Am. Rev. Respir. Dis., 132, 494-497... 

Urbaschek, R., Patscheke, H., Stegmeier, K. and Urbaschek, B. (1985). The effect of a thromboxane receptor blocker in endotoxin shock. Circ. Shock, 16, 71... 

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