Lung injury endotoxin-induced

LPS-induced acute dermatitis Lung reperfusion injury IL-l/LPS-induced acute arthritis Immune complex-mediated acute glomerulonephritis PPD-induced delayed-type hypersensitivity Endotoxemia-induced ARDS-like lung injury Cerebral reperfusion injury Endotoxin-induced pleurisy Acid aspiration-induced lung injury... 

Gonzalez PK et al (1996) Role of oxidant stress in the adult respiratory distress syndrome Evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury. Shock 6 S23-S26... 

Olson, N. C., Kruse Elliott, K. T and Johnson, L. (1990) Effect of LY171883 on endotoxin-induced lung injury in pigs. J. Appl. Physiol. 69, 1315-1322. 

A diet supplemented with GLA and eicosapentaenoic acids improved oxygen delivery by decreasing vascular resistance and increasing cardiac index in endotoxin-induced lung injury in pigs. This mechanism is thought to involve attenuation of endotoxin-induced thromboxane B2 synthesis (Murray et al., 1995). A study (Mancuso et al., 1997) in endotoxic rats demonstrated that in addition to attenuation of thromboxane B2 production, production of leukotriene B4, leukotriene C/D4, and PGFla,... 

At this time, it is difficult to reconcile the results from all the studies in the literature regarding the role of specific eicosanoids or PAF in the development of endotoxin-induced lung injury. The differences in results may be due to the use of inadequate or ineffective inhibitors, different doses and preparation of endotoxin, variable sensitivity of different species of animals to endotoxin effect and differences in eicosanoid metabolism in different species . A final possibility is that perhaps none of the metabolites alone is adequate to cause injury, but mediator chain reactions and synergistic actions of several mediators are important. This might explain why interventions targeting a single mediator (thromboxane or leukotrienes) have so far met with limited success. 

Wong, C., Fox, R. and Demling, R.H. (1985). Effect of hydroxyl radical scavenging on endotoxin-induced lung injury. Surgery, 97, 300-306... 

Demling, R.H., Winger, H., Hectman, H. and Wong, C. (1985). Role of subcutaneous endotoxin in the production of prostanoid-induced lung injury Comparison with intravenous endotoxin response. Circ. Shock, 17, 147-161... 

Kubo, K. and Kobayashi, T. (1985). Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. Am. Rev. Respir. Dis., 132, 494-497... 

Blumenthal S, Borgeat A, Pasch T, Reyes L, Booy C, Lambert M, Schimmer RC, Beck-Schimmer B. Ropivacaine decreases inflammation in experimental endotoxin-induced lung injury. Anesthesiology 2006 104(5) 961-9. 

Nichol, A. D. O Cronin, D. E Naughton, E Hopkins, N. Boylan, J. McLoughlin, P. Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury. Anesthesiology 2010, 113,116-125. 

---