Thrombosis factors regulating

Regulating anticlotting factors that affect blood coagulation and thrombosis... 

Thrombin (factor Ha) is the last enzyme protease involved in the coagulation cascade, and it converts fibrinogen to insoluble fibrin that forms the fibrin gel either in physiological conditions or in a pathological thrombus (28). Thrombin has also hormonelike properties, and it is involved in thrombosis and platelet activation. Therefore, thrombin plays a central role in a number of cardiovascular diseases (29), and it is thought to regulate many processes in inflammation and tissue repair at the vessel wall. 

Zimmerman, G.A. et al. The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med. 30 (2002) S294-S301. 

Di Santo, A., Mezzetti, A., Napoleone, E., Di Tommaso, R., Donati, M.B., De Gaetano, G., et al. 2003. Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. Journal of Thrombosis and Haemostasis, T. 1089-1095. Dohadwala, M.M. and Vita, J.A. 2009. Grapes and cardiovascular disease. J Nutr. 739 1788S-1793S. 

Amento, E.P., N. Ehsani, H. Palmer, and P. Libby. 1991. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arteriosclerosis and Thrombosis 11(5) 1223-1230. 

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