Thromboresistant biomaterials

Mowery KA, Schoenfisch MH, Saavedra JE, Keefer LK, Meyerhoff ME. Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release. Biomaterials 2000, 21, 9-21. 

Oh BK, Meyerhoff ME. Catalytic generation of nitric oxide from nitrite at the interface of polymeric films doped with lipophilic Cu(II)-complex a potential route to the preparation of thromboresistant coatings. Biomaterials 2004, 25, 283-293. 

Members of the biomaterials community continue to search for experimental animal models that assess the thromboresistance of polymers. We developed a new animal model involving rapid, simple retrograde cannu-lation of the goat s carotid arteries. The method promises to assess potential biomaterials, evaluate drugs that may decrease thrombus growth, and measure real-time thrombus growth and dissolution. A critical aspect of this new experimental model is that the continuously monitored net platelet retention data can be modeled mathematically. 

Thierry B, Winnik FM, Merhi Y, Silver J, Tabrizian M. Radionuclides-hyaluronan-conjugate thromboresistant coatings to prevent in-stent restenosis. Biomaterials 2004 25 3895-3905. 

Baier, R., 2002, Thirty years of thromboresistance How it has heen obtained, founders award address. Proceedings of the Annual Meeting, Society for Biomaterials, Minneapolis, MN. 

Arnander, C., Bagger-Sjoebaeck, D., FrebeUus, S., Larsson, R., Swedenborg, J. Long-term stability in vivo of a thromboresistant heparinized surface. Biomaterials 8(6), 496-499 (1987)... 

Very shortly after this finding, a concerted effort was begun in 1964 to find or develop thromboresistant pol3rmers. This effort was the biomaterial portion of the Artificial Heart Program of the National Heart Institute, Descriptions of the approaches taken and progress made have been published in some detail. The early work on individual polymers is not described or referenced here because of space limitation. Consult references (2) and (3) for more specific information. These early efforts were in directions such as ... 

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