Hyaluronan conjugates

Thierry B, Winnik FM, Merhi Y, Silver J, Tabrizian M. Radionuclides-hyaluronan-conjugate thromboresistant coatings to prevent in-stent restenosis. Biomaterials 2004 25 3895-3905. 

Figure 7.4 Carbohydrate-functionalized ROMP polymers for binding (a) L-selectin and (b) concanavalin A. (c) Hyaluronan-conjugated PNBE. (d) Poly(5,5-dihydroxyoxanorbornane carboxylic acid).

Recently, other approaches and modifications of HA for gene delivery applications have been investigated. Among the most interesting ones are mixed chitosan-hyaluronan based gene delivery systems [68-70] and PEG-HA photocrosslinked hydrogels [71]. HA has also been used to improve the biocompatibility of branched PEI via covalent conjugation [72],... 

Figure 1 Structure of bupivacaine conjugated to the Hyaluronan (HA) backbone by a...

Figure 2 Structure of paclitaxel conjugated via an acyl hydrazide bond to the Hyaluronan...

Ruhela, D., Riviere, K., Szoka, F. C. Efficient synthesis of an aldehyde functionalized hyaluronic acid and its appUcation in the preparation of hyaluronan-hpid conjugates. Bioconjugate Chem. 2006, v. 17. Iss. 5, 1360-1363. 

Cai and co-workers developed a conjugate of hyaluronan (HA) with DOX via hydrazone linkage for localized chemotherapy of breast tumor cells. The HA-DOX nanoconjugate exhibited sustained release characteristic, reduced toxicity, and inhibited breast cancer progression in xenografts of human breast cancer, leading to an increased survival rate [48],... 

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