Threshold change

Mec-precipitated somatically expressed withdrawal behaviors Mec-precipitated somatically expressed withdrawal behaviors Mec-precipitated somatically expressed withdrawal behaviors Naloxone-precipitated somatically expressed withdrawal behaviors Somatically expressed behaviors precipitated by mec in VTA less threshold changes induced by DA antagonist SCH3390-Withdrawal precipitated by systemic mec Spontaneous withdrawal... 

SAFETY PROFILE Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route convulsions or effect on seizure threshold, change in motor activity, change in kidney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Na20. 

Rubin, L. S., Goldberg, M. N. (1958). Effect of tertiary and quaternary atropine salts on absolute scotopic threshold changes produced by an anticholinesterase (sarin). Journal of Applied Physiology, 12, 302-310. 

Rubin LS and Goldberg MN (1957b). Effect of sarin on dark adaptation in man threshold changes. J Appl Physiol, 11, 439-444. 

Maximum allowable concentrations (MACs) for pesticides in water must take into account the effects on palatability and sanitary status. These data are compared with toxicological research to define an index of limits for use in establishing the MAC. If the organoleptic properties of water are affected by pesticide concentrations lower than those that produce threshold changes in tests on animals, palatability becomes the limiting index. If toxic alterations occur at concentrations that do not render the water unpalatable, the standard is set on the basis of toxicological criteria. Standards are established in a similar way for air. 

Sensory systems Auditory and vestibular function In 93 patients with acute uncomplicated malaria auditory function was tested before and after a 3-day course of artesunate 4 mg/kg/day combined with mefloquine 25 mg/kg, using tympanometry, audiometry, and auditory brain stem response [26 ]. Hearing loss on day 0 was common (57%) and was associated with age only. However, no patient had a threshold change exceeding 10 decibels between day 0 and day 7 at any tested frequency, and none had a shift in wave III peak latency of more than 0.3 msec between baseline and day 7. Thus, there was no evidence of auditory toxicity in these patients 7 days after a course of artesunate and mefloquine. 

---