Thl7 cells

PAMPs and various tissue factors can prime DCs to produce T-cell-polarizing factors [21], IL-12 is a pro-inflammatory cytokine that induces IFN-y and promotes the development of Thl-cell differentiation [31], Other Thl-polarizing factors are IFN-a and IFN-(3 [32] and cell-surface expressed intracellular adhesion molecule (ICAM)-l [33]. On the other hand, it has been shown that NF-kB inducing kinase (NIK), which is known to regulate B-cell maturation and lymphoid organogenesis, is important for the induction of Thl7 cells [34],... 

In 2006, another subset of Th cells was recognized, known as Thl7 cells [89]. These cells have been described to exert major functions in induction of tissue inflammation and... 

TGF-(3-treated T cells into pro-inflammatory Thl7 cells in favor of iT cells differentiation [67, 70]. The use of retinoic acid congeners as therapeutic agents in boosting oral tolerance is thus of intense current interest. 

Fig.1. SchematicT-cell development. Upon antigen encounter, DCs are activated to secrete different cytokines. Each cytokine or the combination of different cytokines can determine the cell type present in the airways of asthmatic subjects. Particularly complicated is the development of Thl7 cells which can develop either upon IL-23 exposure and/or TGF-(3 a combined to IL-6. In the absence of IL-6, Thl7 cells develop under the influence of TGF-(3 and IL-21. Under this latter condition, Thl 7 cells coexist with theTregs.

Tregs and effector T cells, so that naive CD4-F T cells differentiate into Foxp3-F Tregs in the presence of TGF-(3 or into Thl7 cells in the presence of TGF-(3 and IL-6. Thus T-cell activation in the... 

Thl7 cells in the circle of immunity and autoimmunity. Nat Immunol 2007 8 345-350. 

Kang HK, Liu M, Datta SK Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-spe-cific regulatory T cells and contraction of inflammatory Thl7 cells. J Immunol 2007 178 7849-7858. 

Ma HL, Liang S, Li J, Napierata L, Brown T, Benoit S, Senices M, Gill D, Dunussi-Joannopoulos K, Collins M, Nickerson-Nutter C, Fouser LA, Young DA (2008) IL-22 is required for Thl7 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 118 597-607... 

Re5molds, A.D., Stone, D.K., Hutter, J.A.L., et al. Regulatory T cells attenuate Thl7 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson s disease. J. Immunol. 184, 2261-2271 (2010). doi 10.4049/jimmunol.0901852... 

CXCR4 CXCL12 Neutro, eosino, baso, mono/m4>, immature mDC, mature mDC, pDC, naive T cell, memory Tcell, Thl cell, Th2 cell, Thl7 celL Treg cell, B cell, NK cell, platelets... 

CCR6 CCL20 Immature mDC, memory T cell, Thl7 cell, Treg cell, B cell... 

---