Thl7 cell differentiation

PAMPs and various tissue factors can prime DCs to produce T-cell-polarizing factors [21], IL-12 is a pro-inflammatory cytokine that induces IFN-y and promotes the development of Thl-cell differentiation [31], Other Thl-polarizing factors are IFN-a and IFN-(3 [32] and cell-surface expressed intracellular adhesion molecule (ICAM)-l [33]. On the other hand, it has been shown that NF-kB inducing kinase (NIK), which is known to regulate B-cell maturation and lymphoid organogenesis, is important for the induction of Thl7 cells [34],... 

TGF-(3-treated T cells into pro-inflammatory Thl7 cells in favor of iT cells differentiation [67, 70]. The use of retinoic acid congeners as therapeutic agents in boosting oral tolerance is thus of intense current interest. 

Tregs and effector T cells, so that naive CD4-F T cells differentiate into Foxp3-F Tregs in the presence of TGF-(3 or into Thl7 cells in the presence of TGF-(3 and IL-6. Thus T-cell activation in the... 

Fig.1. Differentiation ofT cells content of micromilieu and several cytokines and other cofactors released from DCs are essential for the differentiation of naive T cells into T-helper(Th)l,Th2,Th9,Thl7 effectorT-cell subsets. 

Iwamoto S et al. TNF-alpha drives human CD 14-I- monocytes to differentiate into CD70-I- dendritic cells evoking Thl and Thl7 responses. J Immunol 2007 179 1449-1457. 

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