Thiothixene

A solution of 30.3 parts of triethylamine and 12.9 parts of ethylenimine in 180 parts of dry benzene is treated with a solution of 16.9 parts of thiophosphoryl chloride in 90 parts of dry benzene at 5°C to 10°C. Triethylamine hydrochloride is filtered off. The benzene solvent is distilled from the filtrate under reduced pressure and the resulting crude product is recrystallized from petroleum ether. The N,N, N -triethylenethiophosphoramide had a melting point of 51.5°C. 

Chemical Name (Z)-N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene] thioxanthene-2-sulfonamide 

Chemical Abstracts Registry No. 3313-26-6 Trade Name Manufacturer 

Thioxanthene Thionyl chloride n-Butyllithium Paraformaldehyde Sodium borohydride 

Chlorosulfonic acid Dimethylamine Methyl acetate 1-Methylpiperazine Phosphorus oxychloride 

The crude sulfonate product was digested in 1,500 ml of boiling water, and filtered at the boiling point. Crystallization was allowed to proceed overnight at 4 C and after filtration and vacuum drying at 100°C, 33.3 grams (69%) of glistening, colorless plates were obtained. 

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Butyl lithium Doxepin HCI Gemfibrozil Thiothixene Zimel idine... 

Benzethonium chloride Bephenium hydroxynaphthoate Camazepam Dibutoline sulfate Doxepin HCI Furtrethonium iodide Loperamide HCI Thiothixene... 

The answer is b. (Katzung, p 4822) Haloperidol, a butyrophenone, is by far the most likely antipsychotic to produce extrapyramidal toxicides Other agents, such as piperazine (an aromatic phenothiazine), thiothixene (a thioxanthene), and pimozide (a diphenylbutyropiperidine) are comparitively less likely to produce extrapyramidal toxicity than haloperi-dol. The antagonism of dopamine in the nigrostriatal system might explain the Parkinson-like effects Both haloperidol and pimozide act mainly on D2 receptors, whereas thioridazine and piperazine act on ooadrenergie receptors, and have a less potent but definite effect on D2 receptors. 

The tranquillizers flupenthixol (353), clopenthixol (354), chlorprothixene (355) and thiothixene (356) showed batch-to-batch variation in their cisjtrans isomer ratio. 

Whatever the underlying causes may be, neuroleptic medications are the most effective treatment for schizophrenia. All antipsychotic medications have some form of dopamine receptor antagonism and they are distinguished by their chemical class. The phenothiazines include chlorpromazine (Thorazine), thioridazine (Mellaril), mesoridazine (Serentil), trifluoperazine (Stelazine), fluphenazine (Prolixin), and prochlorperazine (Compazine). The thioxanthenes include chlorprohixine (Taractan) and thiothixene (Navane). Butyrophenones are represented by haloperidol (Haldol). Loxapine (Loxitane) is a dibenzoxapine, and molindone (Moban) is a dihydroindolone. 

Thiothixene (Navane). Thiothixene is sometimes grouped with the medium potency and at other times with the high potency antipsychotics. Its potency is actually about halfway between these two groups. Thiothixene is available in both oral and injectable forms. It should be initiated at doses of about 5mg/day and can be... 

Trifluoperazine (Stelazine). Trifluoperazine is very similar to thiothixene. It comes in both oral and injectable forms. Its dose range is the same as thiothixene. 

Thioridazine (Mellaril) Antipsychotic Thiothixene (Navane) Antipsychotic Tiagabine (Gabatril) Anticonvulsant... 

Thiazinone, synthesis, 280 Thiazosulfone, 141 Thiethylperazine, 382 Thiobarbital, 275 Thiofuradene, 231 Thiopental, 274 Thiopropazate, 383 Thioridazine, 389 Thiothixene, 400 Thonzylamine, 52 Thrombosis, 397 Thyroid gland, 95 Thyroxine, 95, 97 Tolazamide, 137 Tolazoline, 241 Tolbutamide, 136 Tolycaine, 17... 

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