Thiothixene adverse effects

In one single-blind study, 17 schizotypal patients were given a modest dose of halopehdol (i.e., 2 to 12 mg per day), which produced some benefit, although many were sensitive to the adverse effects of this drug (216). The study by Goldberg et al. (217) also found that thiothixene benefited both schizotypal disorder and borderline personality disorder (BPD). Similarly, low-dose antipsychotics had a modest effect in patients with both schizotypal and obsessive-compulsive personality disorders (218). 

Thiothixene levels are usually increased by TCAs (doxepin and nortriptyline). Additive adverse effects have also been reported when co-administered with ciomipramine (rapid development of tardive dyskinesia). Marked extrapyramidal side-effects have been reported (a few cases only) with suipiride or thiothixene when fluoxetine is added to the regimen. Unlike the established interactions between most phenothiazines and TCAs, in which serum levels of both agents could increase, no apparent interaction is evident to date between fiupenthixoi and imipramine or any other TCA. 

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