Thiols halides

Nucleophilic displacement, for the synthesis of Amines, thiols, halides, azides, acetates [204, 205]... 

The coordination chemistry of palladium and platinum with large aromatic thiolates has been restricted to some studies with PFTPH, although there is an extensive reported chemistry of oligomeric complexes with smaller thiols. Halide complexes of Pd and Pt were shown to react with Tl(PFTP) to give the presumably monomeric, square planar anionic M(II) complexes [M(PFTP)4] (83). 

Hydrogen sulfide ion Alkyl halide Thiol Halide ion... 

Epoxide Opening. LiC104 is an efficient promotor for the regioselective nucleophilic opening of oxiranes with amines, cyanide, azide, thiols, halides, and lithium acetylides. The regioselective opening of oxiranes with lithium enolates derived from ketones has also been observed in the presence of LiC104 (eq 6). ... 

This direct sulphonation should be compared with the indirect methods for the preparation of aliphatic sulphonic acids, e.g., oxidation of a thiol (RSH -> RSOjH), and interaction of an alkyl halide with sodium sulphite to give the sodium sulphonate (RBr + Na,SO, -> RSO,Na + NaBr). 

Mercaptans (or thio-alcohols or thiols), the sulphur analogues of the alcohols, were formerly prepared by the interaction of an alkyl halide and sodium hydrosulphide in alcoholic solution ... 

Aryl sulfides are prepared by the reaction of aryl halides with thiols and thiophenol in DMSO[675,676] or by the use of phase-transfer catalysis[677]. The alkenyl sulfide 803 is obtained by the reaction of lithium phenyl sulfide (802) with an alkenyl bromide[678]. 

It IS not necessary to prepare and isolate the sodium alkanethiolate m a separate opera tion Because thiols are more acidic than water they are quantitatively converted to their alkanethiolate anions by sodium hydroxide Thus all that is normally done is to add a thiol to sodium hydroxide m a suitable solvent (water or an alcohol) followed by the alkyl halide... 

Thiols can be prepared by a variety of methods. The most-utilised of these synthetic methods for tertiary and secondary thiols is acid-catalysed synthesis for normal and secondary thiols, the most-utilised methods are free-radical-initiated, alcohol substitution, or halide substitution for mercaptoalcohols, the most-utilised method is oxhane addition and for mercaptoacids and mercaptonitnles, the most-utilised methods are Michael-type additions. 

Halide Displacement. Hahde displacement is a method used to prepare thiols that are not readily available by normal means. It requires a two-phase, water—organic system, that can be quite corrosive. Normally, this type of reaction, a classic Sj 2 type, is undertaken in HasteUoy or glass-lined... 

Pyrrolethiols, readily obtained from the corresponding thiocyanates by reduction or treatment with alkali, rapidly oxidize to the corresponding disulfides. They are converted into thioethers by reaction with alkyl halides in the presence of base. Both furan- and thiophene-thiols exist predominantly as such rather than in tautomeric thione forms. 

Pyrimidine-2-sulfonyl chloride, 4,6-dimethyl-reactions, 3, 97 Pyrimidinesulfonyl halides reactions, 3, 97 Pyrimidinethiols S-acylation, 3, 95 S-alkylation, 3, 94 oxidation, 3, 94 synthesis, 3, 135 Pyrimidine-5-thiols oxidation, 3, 94 synthesis, 3, 136... 

Three substituted 5-phenyl unsymmetrical disulfides have been prepared, i, ii, and iii —compounds i and ii by reaction of a thiol with a sulfenyl halide, compound iii from a thiol and an aiyl thiosulfonate (ArS02SAr). The disulfides are cleaved by reduction (NaBH4) or by treatment with excess thiol (HSCH2CH2OH). 

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