Thioether continued structure

The first three-dimensional macrobicyclic TTF derivatives have been obtained <96CC615> and work on TTF-containing crown ethers and thioethers has continued <96LA551, 96JCS(P1)1995> with structures of this type being used to obtain the first TTF-containing... 

Over the years, several techniques have been developed to elucidate the structure of a new lantibiotic. The extensive post-translational modifications limit Edman degradation to a stretch of amino acids from the N-terminus to the first modification. Various chemical derivatization techniques have been used to allow continuation of the sequence and to reveal the position of the posttranslationaUy modified residues. Originally, these techniques relied on treatment with ethanethiol under highly basic conditions that result in elimination reactions of the thioethers... 

Synthesis and structural characterization of synthetic analogs of liver alcohol dehydrogenase (LADH) continued to be one of the most investigated fields of research. A number of ligands suitable for modeling LADH have been reported and their hydroxo zinc complexes also described.133-135 [Zn(TmMes)(HOMe)]+, for example, exhibits a coordination environment that resembles aspects of that in LADH.136 The ethanol complex [Zn(Tm Bu)(HOEt)]+ has been also isolated.137 [NS2] donor ligands, that feature thioether donors, also provide coordination environments that mimic the active site of LADH.138,139... 

The low thermal stability of PVC originates from the presence of labile structures and of the autocatalytic deleterious effect of the hydrochloric acid evolved. Thermal stabilizers for PVC consist principally of metal carboxylates and organotin compounds (primary stabilizers), used in combination for preventive and curative functions. As with degradation, uncertainties continue to exist in the exact stabilizing mechanisms of these additives. There is evidence that organotin derivatives stabilize PVC by substituting the labile allylic chorine with a more thermally stable thioether group [Eq. (96)]. 

The structural diversity of macrocyclic a-helical peptides continues to expand with novel chemistiy methodologies. For example, a photoinduced 1,3-dipolar cycloaddition approach for macrocyclization has been introduced as illustrated by the pyrazoline-stapled p53 peptide 25 (Figure 9.8). Interestingly, a bis-thioether macrocyclized a-helical p53 peptide, 26, was determined to exhibit good cellular uptake when conjugated with a... 

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