2-Thienylglycolic acid

Testosterone cypionate cyclopentyl-2-thienylglycolic acid (C11H14O3S 3899-50-1) see Penthienate methobromide cyclopentyl-2-thienylglycolic acid 2-diethylaminoethyl ester... 

The pronounced influence of the phenyl group on optical activity led Fredga and Palm" to initiate an investigation on the optical activity of thiophene derivatives, in order to use this physical property for the elucidation of the aromatic character of thiophene. 2-(27) and 3-Thenylsuccinic acid (28), 2- (29) and 3-thienyl-succinic acid (30), 2- (31) and 3-thienylglycolic acid (32), 2-(33) and 3-a-methoxythienylacetie acid (34), -phenyl 2-thienyl-glycolic acid (35), -(2-thienyl)-y5-phenylpropionic acid (36), a-phenyl- -(2-thienyl) propionic acid (37), a,/ -di (2-thienyl)propionic acid (38) have been resolved into antipodes with the help of optically active bases. 

Earlier investigations have shown that powerful antispasmodic activity occurs in various basic esters of a-substituted thienylglycolic acids, thienylacetic acids, and thienylpropionic acids of the general type (256), (cf. reference 5 for details). One such compound, the... 

Benzo[ ]thienylmagnesium bromide is said to react with dialkyl oxalates at 36-40° to give esters of 2-benzo[6]thienylglyoxalic acid, and at 110-115° to give esters of 2-benzo[6]thienylglycolic acid.898... 

Magnetically non-equivalent thiophenic protons have been observed in thienylglycollic acid esters of certain asymmetric alcohols. ... 

Methyl phenyl-2-thienylglycolate Hydrochloric acid Potassium carbonate... 

A solution of 5.0 g of l-methyl-3-pyrrolidinol and 12.5 g of methyl phenyl-2-thienylglycolate in 200 ml of n-heptane is heated to reflux temperature, a trace of sodium methylate is added, and refluxing of the mixture is continued for 3 h. A Dean-Stark trap is incorporated in the reflux apparatus to separate and withdraw the methanol produced by the reaction. At the end of the reflux period, the reaction mixture is cooled and extracted two times with 100 ml portions of 2 N hydrochloric acid. The acid extracts are combined, basified with potassium carbonate, and extracted three times with 50 ml portions of benzene. The benzene extracts are combined, washed two times with 25 ml portions of water, and dried. The benzene is removed from the dried extract by evaporation at reduced pressure. The residue is l-methyl-3-pyrrolidylphenyl-2-thienylglycolate in the form of a clear liquid. 

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