Thiamin anhydride

An x-ray crystallographic analysis of thiamin anhydride derivative 386 shows that the thietane ring is planar when the formamide nitrogen and sulfur atoms are... 

Methylenethietanes may be oxidized to the sulfones by hydrogen peroxide.Thiamin anhydride 394 is deformylated and converted to the... 

Several products are obtained from the reaction of thiols with thiamine anhydride (50a). A conjugated system is postulated as an intermediate with initial 1,2 addition. The reaction products depend subtly on the pH 9,... 

Sulphur- and phosphorus-containing four-memhraed rings have been examined in iV-(p-bromophenylcarbamoyl)thiamine anhydride (16), cis-2,2,3,4,4-pentamethyl-l-phenylphosphetan 1-oxide (17), the cyclic oxy-phosphorane (18), and l,3-di-t-butyl-2,4-dichlorodiazadiphosphetidine (19). Whereas the four-membered ring of (16) is virtually planar, the rings... 

An ice-cooled soln. of thiamine anhydride in dimethylformamide satd. with HgS, and stored 5 days at room temp, in a sealed tube -> N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[l-(l,2-dithiolan-3-yl)ethyl]formamide. Y 91%. A.Takami-zawa, K. Hirai, and T. Ishiba, Chem. Pharm. Bull. 19, 1022 (1971). 

Cl9H1bOSs, 2-p-Methoxyphenyl-4,5-(l-(1,3-dithiolane-2-ylidene)-tet-ramethylene)-1,6,6a-thiathiophthene, 40B, 324 Cl9H2oBrNs02S, N-(p-Bromophenylcarbamoyl)thiamine anhydride (N,S-cis-TypeK 38B, 361... 

C19H17N2S2, 3-Phenyl-8-phenylthiocarbamoyl-6,7-dihydro-5H-thiazolo-[3,2-a]pyrimidinium-betaine, 4IB, 441 Cl9H18CI3NO2S, 1,4-Dihydro-1-methyl-4-(2-methyl-5-phenylthiopyran-4-ylidene)pyridine SS-dioxide chloroform solvate, 39B, 280 Cl9H2oBrNs02S, N-(p-Bromophenylcarbamoyl)thiamine anhydride, 37B,... 

Thiamine anhydride (77) is a useful source of sulphur analogues of thiamine. Thus, it reacts with thioacetic acid to give the thiazolinethione (78), which on successive desulphurization by the action of hydrogen peroxide and treatment with barium chloride affords acetylthioethylthiamine (79) hydrolysis finally produces mercaptoethylthiamine (80), the sulphur analogue of thiamine. This is convertible into further derivatives, particularly by replacement of the mercapto-group of the 5-side-chain by amino-, sul-phenyl-, sulphinyl-, and sulphonyl-residues [e.g. (81), (82)]. ... 

TOBACCO [NicoTiANA TABACUM L.) Fractions M-Ia and M-Ib from acid phosphatase of tobacco cells did not hydrolyse phosphate monoesters except para-nitrophenyl phosphate, but hydrolysed phosphoric anhydrides (inorganic pyrophosphate, thiamine pyrophosphate, nucleoside di- and triphosphates). In addition, both fractions hydrolysed bis-para-nitrophenyl phosphate. Fraction M-II, a non-specific acid phosphatase, had broad substrate specificity it hydrolysed pyrophosphate, thiamine pyrophosphate, uridine diphosphate, adenosine triphosphate, uridine triphosphate, and cytidine triphosphate, at rates similar to para-nitrophenyl phosphate (Ninomiya et al., 1977). 

L-Alanine Carotene Cholecalciferol Choline bitartrate Chondroitin sulfate Copper iodide (ous) DL-Leucine Linolenic acid Olive (Olea europaea) oil Pancreatin D-Phenylalanine DL-Phenylalanine Propionic anhydride Silicon Sodium chloride Sugar cane (Saccharum officinarum) extract Thiamine HCI Vipers bugloss (Echium plantagineum) oil... 

Stumpf etal reacted MA with cis, trans, // (2 5-l,5,9-cyclododecatriene 36 in the presence of phenothiazine or thiamine as an inhibitor. The product cis, trans, /raAi5-2,5,9-cyclododecatrienylsuccinic anhydride 37 was obtained in yields as high as 76%. MA could be substituted in this reaction with maleic... 

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