Thermoregulatory effects

Glick, S.D. and Guido, R.A. Naloxone antagonism of the thermoregulatory effects of phencyclidine. Science 217 1272 - 1274,... 

Woodward S, Freedman RR (1994) The thermoregulatory effects of menopausal hot flashes on sleep. Sleep 17 497-501... 

Zhang Q, Spiers DE, Rottinghaus GE, Gamer GB. Thermoregulatory effects of ergo valine isolated from endophyte-infected tall fescue seed on rats. J Agric Food Chem 42 954-958, 1994. 

E.E. Hac and I T. Gagalo, Copper Salicylate Complex. I Thermoregulatory effects. First World Conference on Inflammation Antirheumatics, Analgesics, and Immunomodula-tors. Venice, Italy, April 16-18, 1984. 

Thermoregulatory effects, creating a microclimate resulting from either heat absorption or heat emission, keeping the temperature of the surroundings almost constant... 

The result of a PCM is a tailor-made thermoregulatory effect, though this can only be achieved if the PCM is optimally positioned. For this, certain design principles must be taken into account... 

Humans and the other warm-blooded animals have developed thermoregulatory systems to carefully control body temperature to levels that enable them to function and survive effectively. In general, thermal comfort occurs when the physiological effort to control body temperature is minimized for the activity. Table. 5.1... 

Fever is the most common manifestation. The thermoregulatory centre in the hypothalamus regulates body temperature and this can be affected by endotoxins (heat-stable lipopolysaccharides) of Gram-negative bacteria and also by a monokine secreted by monocytes and macrophages called interleukin-1 (IL-1) which is also termed endogenous pyrogen. Antibody production and T-cell proliferation have been shown to be enhanced at elevated body temperatures and thus are beneficial effects of fever. 

Vasodilation of tail vessels has been observed in rats following exposure to 4 mg/kg/day chlordecone for 90 days (Larson et al. 1979b). The cause of the vasodilation was not investigated but was suggested to have been associated with altered thermoregulatory mechanism (see Other Systemic Effects, below). 

Cook LL, Gordon CJ, Tilson HA, et al. 1987. Chlordecone-induced effects on thermoregulatory processes in the rat. Toxicol Appl Pharmacol 90 126-134. 

Every componnd of this series differs to a certain degree from the other in their qualitative, yet primarily quantitative characteristics. They all act on the CNS by causing moderate sedative and antiemetic effects, affecting thermoregulatory processes, skeletal muscle, endocrine system, and by potentiating action of analgesics. 

Injection studies have shown that nickel can decrease body temperature (Gordon 1989 Gordon et al. 1989 Hopfer and Sunderman 1988 Watanabe et al. 1990). Because nickel also disturbs the circadian rhythm of temperature regulation, this decrease is thought to result from an effect on the central nervous system. It has been speculated that nickel may mimic the effect of calcium on the hypothalamic thermoregulatory center resulting in hypothermia (Hopfer and Sunderman 1988). 

Atropine suppresses thermoregulatory sweating. Sympathetic cholinergic fibers innervate eccrine sweat glands, and their muscarinic receptors are readily accessible to antimuscarinic drugs. In adults, body temperature is elevated by this effect only if large doses are administered, but in infants and children even ordinary doses may cause "atropine fever."... 

Beredek, G. and Szikszay, M. Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists, Pharmacol. Res. Commun. 1984, 16, 1009-1018. 

Mechanism of action The antipyretic and anti-inflammatory effects of the salicylates are due primarily to the blockade of prostaglandin synthesis at the thermoregulatory centers in the hypothalamus and at peripheral target sites. Furthermore, by decreasing prostaglandin synthesis, the salicylates also prevent the sensitization of pain receptors to both mechanical and chemical stimuli. Aspirin may also depress pain stimuli at subcortical sites (that is, the thalamus and hypothalamus). 

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