Thermophiles translation

Cold-shock proteins (Csps) are transiently expressed at a higher level in bacteria as a response to an abrupt decrease from normal physiological temperature. Their exact biological function is still unknown, but translational regulation, possibly via RNA chaperoning, has been discussed. " Csps from mesophiles and thermophiles differ widely in their stability, but show... 

The salient features of in vitro translation systems from halophiles, methanogens, and from sulfur-dependent thermophiles belonging to both archaeal kingdoms are summarized below. 

MnSODs and FeSODs from most procaryotic organisms are dimeric while MnSODs from mitochondria and some thermophilic bacteria are tetrameric [21]. However, mitochondrial MnSOD from Caenorhahditis elegans was found to be dimeric [22]. Eukaryotic MnSOD is a tetrameric protein encoded in the nucleus, synthesized in the cystosol, and imported post-translationally into the mitochondrial matrix. The 25 kDa precursor protein has a mitochondrial transit peptide that is cleaved to produce the mature 22 kDa subunit. The mature protein exists as a tetramer, each subunit containing one Mn ion. The mitochondrial MnSOD primary sequences are highly homologous to the prokaryotic Mn- and FeSOD, but has no resemblance to the CuZnSODs [23]. In MnSODs and FeSODs, the metal ions are coordinated by three His N atoms and one Asp O atom [24]. 

Role of modified nucleosides in the translation function of tRNAs from extreme thermophilic bacteria and animal mitochondria 07BCJ1253. 

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