Bacteriophage therapy

Keywords Bacteriophage therapy Bioterrorism Biological warfare... 

Within the former Soviet Union (FSU), bacteriophage therapy was researched and extensively applied for the treatment and prophylaxis of a wide range of bacterial infections. In the West however, it was not explored with the same enthusiasm and was eventually discarded with the arrival of antibiotics. 

Beridze MA (1938) Role of bacteriophage therapy in combating of purulent skin infections. Tbilisi, Georgia... 

Sulakvelidze A, Alavidze Z, Morris JG, Jr, Bacteriophage therapy. Antimicrob. Agents Che-mother. 2001, 45, 649-659. 

Novel Bacteriophage Therapies for Vibrio Cholerae Infection... 

NAKAi T and PARK s c (2002) Bacteriophage therapy of infectious diseases in aquaculture, Res Microbiol, 153,13-18. 

Sulakvelidze, A., Alavidze, Z., and Morris, J.G. Jr. (2001) Bacteriophage therapy. Antimicrob Agents Chemother 45, 649-659. 

Yihnaz, C., Colak, M., Yihnaz, B.C., Ersoz, G., Kutateladze, M., Gozlugol, M., 2013. Bacteriophage therapy in implant-related infections an experimental study. J. Bone Joint Surg. Am. 95, 117-125. 

LOC CARRILLO, C., ATTERBURY, R. J., EL-SHIBINY, A., CONNERTON, P. L., DILLON, E., SCOTT, A. CONNERTON, I. F. (2005) Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens. Applied and Environmental Microbiology, 71,6554. 

E. G. (2007) Furunculosis in Atlantic salmon (Salmo solar L.) is not readily controllable by bacteriophage therapy. Aquaculture, 270,475-484. 

Vartapetov LI (1957) Phage therapy of deep forms of piodermitis caused by Staphylococcus, In Bacteriophages , Tbilisi, Georgia, pp 411-422... 

Walsh (2003) defined biopharmaceuticals as therapeutic protein or nucleic acid preparations made by techniques involving recombinant deoxyribonucleic acid (DNA) technology. Therapeutic proteins include blood clotting factors and plasminogen activators, hemopoietic factors, hormones, interferons and interleukins, and monoclonal antibodies (LeVine, 2006). Over time, the term biopharmaceutical has broadened, and, in addition to proteins and nucleic acids, now includes bacteriophages, viral and bacterial vaccines, vectors for gene therapy, and cells for cell therapy (Primrose and Twyman, 2004). Attention here focuses on proteins, since the majority of approved biopharmaceuticals are proteins. 

Use of microorganisms for drug delivery to the brain Bacteriophages for brain penetration Bacterial vectors Cell therapy... 

The divasity of materials that can be appended to the CPMV coat protein using dick chemistry was furtha demonstrated when the Finn and Manchesta labs attached fullerenes (bucky-balls ) to the exterior surface of the virus. By using dick chemistry, the hydrophobic Cso molecules could be attached to the CPMV capsid, as well as the capsid of bacteriophage Q(3, allowing for solubilization of the highly hydrophobic fullerene. The modified capsids wae readily taken up by cdls, and the authors proposed that the buckyballs could be used as photosensitizers for cancer therapy in future applications. 

Pranjol, M.Z., Hajitou, A., 2015. Bacteriophage-deiived vectors for targeted cancer gene therapy. Viruses 7, 268-284. 

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