Therapeutic discoveries

Sin L, Carducci M, Pearce L, et al. (2005) AACR-EORTC-NCI Int Conf on Molecular Targets and Cancer Therapeutics Discovery, Biology, and Clinical Applications, Philadelphia, November 14-18, 217 (Abstract C77)... 

This work was supported by NIH R01 AI083234 to E.A.A. the Minnesota Supercomputing Institute for Advanced Computational Research (MSI) and the University of Minnesota Institute for Therapeutics Discovery and Development (ITDD). 

Antonella Pepe, Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA... 

Elvin-Lewis, M. 2002. Neem From ethnodentistry to dental products A review of its antiodonto-pathic potential. In Proceedings of World Neem Conference, University of British Columbia, Vancouver, Canada, (H. Behl, ed.), pp. 176-186. Neem Foundation, Mumbai, India. Elvin-Lewis, M. 2003. New therapeutic discoveries from ethnomedical and ethnobotanical data. 

This chapter deals with the various strategies leading to active compounds and active compounds collections. The objective is to identify original starting points for therapeutic discovery programs. Such programs typically begin with the search for hits. ... 

Somogyi, R., and L. D. Greller. 2001. The dynamics of molecular networks Applications to therapeutic discovery. Drug Discov Today 6 1267-77. 

The H2 Receptor and Its Ligands. The discovery of H2 receptors and antagonists occurred in 1972. This topic, including therapeutic implications, is considered in more detail elsewhere (see GASTROINTESTINAL AGENTS). 

It is over three centuries since cinchona bark came into use in European medicine, and no other natural drug has had so much written about it. There are the stories, sometimes legendary, of its discovery by Europeans, vigorous early discussions of its therapeutic value, the destruction of the S. American cinchona trees to meet the demand for bark, the labours of botanical explorers in collecting seed for the formation of plantations, the establishment and development of these plantations in Ceylon, India and Java, the competition between them, the gradual emergence of Java as the world s most important source of supply of cinchona bark, and the development of the manufacture of quinine sulphate in Europe, the United States and the Tropics. ... 

The narrow therapeutic range of digitalis related cardiotonic agents has resulted in an extensive effort to identify compounds in other structural classes which will improve cardiac function. The discovery of the heterocyclic cardiotonic drug, amrinone, led to research on other heterocyclic compounds for that indication. The imidazopyridine, isomazole (57), is representa-... 

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