Therapeutic agents starch

The concentration and the type of disintegrating agent used in a tablet dosage form can greatly influence the dissolution and bioavailability of a therapeutic agent. The dissolution rate is usually increased when the concentration of starch is increased in a tablet formulation. The effect of... 

In spite of recent developments and research in synthetic polymers applied in pharmaceutical field, biomaterials, particularly polysaccharides like starch, cellulose, gums and mucilages, have a greater role to play in pharmaceutical formulation development. It is concluded from the discussion in this entry that because of some limitations at the molecular level, there is a need to modify the parent structure of starch to make it available for pharmaceutical and other industrial uses. Physically and chemically modified starches showed very promising results in the delivery of therapeutic agents. The modified starches have enormous potential to be used in drug delivery because of its easy modification and biodegradability. 

Perfluorochemical oxygen earners are not soluble in water. Therefore, perfluori-nated chemicals cannot be administered in the pure form but have to be converted to an aqueous emulsion. A surfactant, selected for its effectiveness and biochemical compatibility, serves as an emulsifier. Osmolarity and oncotic pressures are adjusted by adding electrolytes and oncotic agents, such as hydroxyethyl starch. Nutrients, thrombolytic agents, therapeutic agents, and other additives may be included in the emulsion, depending on the particular clinical application of the emulsion. 

---