Theophylline sodium glycinate

One commonly administered drug in these infants is theophylline which is used in the treatment of apnoea. In order to examine the feasibility of delivering this drug, a simple gel formulation containing 15J theophylline sodium glycinate in 5% hydroxymethyl cellulose was prepared [JJ2,]. This formulation was chosen using the kinetic model such that the input rate of theophylline produced plasma levels in the therapeutic range 4 to 12 mg/1. Thirteen infants were studied and in all but two cases therapeutic levels... 

Theophylline, 1011 in sport, 98 (metabolite), 421 quantification in plasma, 26 therapeutic drug monitoring, 110 Theophylline, anhydrous, 1011 Theophylline cholinate, 1011 Theophylline ethylenediamine compound, 1011 Theophylline hydrate, 1011 Theophylline monoethanolamine, 1011 Theophylline monohydrate, 1011 Theophylline olamine, 1011 Theophylline sodium aminoacetate, 1011 Theophylline sodium glycinate, 1011 Theophylline-7-acetic acid, 310 Theophylline-aminoisobutanol, 408 Theospan, 1011 Theovent, 1011 Thephorin, 880 Theralax, 397 Theralene, 1046 Therapav, 848... 

MUSCLE relaxant, CARDIAC STIMULANT and VASODILATOR properties. Clinically, it can be used as a BRONCHODILATOR in treating obstructive airways disease, including as an ANTIASTHMATIC in acute attacks. It is often used in the form of derivatives, especially aminophylline. theophylline ethylenediamine aminophylline. theophylline sodium glycinate [usan] is a compound of theophylline with sodium glycinate. It has CARDIAC STIMULANT, SMOOTH MUSCLE RELAXANT and VASODILATOR properties. 

An equilibrium mixture of theophylline sodium (C7H7N4Na02 = 202.1) and glycine (C2H5NO2 = 75.07) in approximately equimolecular proportions, buffered with an additional mole of glycine. 

Sodium glycinate, Biophyltme. Englate, Clytheonale, Nuel-in, Panophytline. Equimolar mixture of theophylline sodium and glycine. Prepn KiAiHz et a ., J. Am. Pharm. Assoc. 36, 248 (1947). Darkens at 180". Soly in water 18% w/v. Satu rated soln has a pH of 8,7-9.1, d20 1.05, and is stable to carbon dioxide. 

A poorly water-soluble active substance such as theophylline becomes soluble by the addition of glycine and sodium hydroxide. In this way a theophylline rectal solution (Table 11.14) can be formulated with theophylline as sodium glycinate. 

Theophylline can be dissolved by salt formation with ethylenediamine or other amines. Previously, ethylene-diamine theofyllinate (aminophylline) was used in oral preparations. Soluble double salts of theophylline can be prepared using sodium acetate and sodium glycinate. However, excellent absorption is achieved after oral administration of theophylline as such, for example in capsules, so... 

---