Theophylline interactions

Yao C, Kunze KL, Kharasch ED, et al. Fluvoxamine-theophylline interaction gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clin Pharmacol Ther 2001 70 415 424. 

Theophylline [the OFF i lin] is a bronchodilator that relieves airflow obstruction in chronic asthma, and decreases the symptoms of the chronic disease. Previously the main-stay of asthma therapy, theophylline has been largely replaced with (3-agonists and corticosteroids. Theophylline is well absorbed by the gastrointestinal tract, and several sustained-release preparations are available. The drug has a narrow therapeutic window, and an overdose of the drug may cause seizures or potentially fatal arrhythmias. Further, theophylline interacts adversely with many drugs. See pp. 450-451 for a description of newly approved drugs, zileuton, zafirlukast, and montelukast. 

JE Jackson, RJ Powell, M Wandell. Cimetidine-theophylline interaction. Pharmacologist 22 231, 1980. 

Grasela TH Jr, Dreis MW. An evaluation of the quinolone-theophylline interaction using the Food and Drug... 

CYP3A4 is primarily responsible for tacrohmus biotransformation in the liver, but it has only a minor role in theophyhine metabolism. It is therefore surprising that this tacrohmus-theophylline interaction occurred. The authors suggested that as long as renal function remains stable, low-dose theophylhne can be used in transplant patients with erythrocytosis, provided that tacrohmus concentrations are closely monitored. 

Intorre, L., Mengozzi, G., Maccheroni, M. et al. (1995) Enrofloxacin-theophylline interaction influence of enrofloxacin on theophylline steady-state pharmacokinetics in the Beagle dog. Journal of Veterinary Pharmacology and Therapeutics, 18,352-356. 

Jackson JE, Powell RJ, Wandell M. Cimetidine-theophylline interaction. Pharmacologist 1980 22 231. 

Cohen, I. A. et al., Cimetidine-theophylline interaction effects of age and cimetidine dose, Ther. Drug Monit., 7(4) 426 34, 1985. 

Meibohm, B. and Wegener, S., Mexiletine-Theophylline-Interaction, Krankenhaus-pharmazie, 13(7) 331-333, 1992. 

Luskin SS, Fitzsimmons WE, MacLeod CM, Luskin AT. Pharmacokinetic evaluation of the terfenadine-theophylline interaction. J Allergy Clin Immunol (1989) 83, 406-11. 

Griffith JA, Kozloski GD. Isoproterenol-theophylline interaction possible potentiation by other drugs. ClinPharm (1990) 9, 54-7. 

Colli A, Buccino G, Cocciolo M, Parravicini R, Elli GM, Scaltrini G. Ticlopidine-theophylline interaction. ClinPhannacol Ther ( 9S1) 41, 358-62. 

Roberts RK, Grice J, McGuffie C. Cimetidine-theophylline interaction inpatients with chronic obstructive airways disease. MedJAust (1984) 140, 279-80. 

Hegm an GW, Gilbert RP. Ranitidine-theophylline interaction — fact or fiction DICP Am Pharmacother (1991) 25, 21-5. 

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