Theo - Aminophylline

Twenty years ago theophylline (Theo-Dur, Slo-bid, Uniphyl, Theo-24) and its more soluble ethylenedi-amine salt, aminophylline, were the bronchodilators of choice in the United States. Although the p2-adreno-ceptor agonists now fill this primary role, theophylline continues to have an important place in the therapy of asthma because it appears to have antiinflammatory as well as bronchodilator activity. 

Brand Name(s) (aminophylline) Phyllocontin, (theophylline) Elixophyllin, Quibron-T, Quibron-T/SR, Slo-bid Gyrocaps, Theo-24, Theochron, Theodur, Theolair, Theolair-SR, T Phyl, Uniphyl... 

This is theophylline or aminophylline (theophylline plus ethylene diamine) sio-bid , Bronkodyi , Theo-Dur , etc. available in capsules, caplets, liquids, elixirs, syrups, suspensions. 

Example Theophylline (Theo-Dur, Theophyllines, Kl, Slo-Phyllin, Slo-BID Aminophyllin) Route PO Pregnancy category C Pharmacokinetic Metabolized by hver and 90% excreted in urine... 

Theophylline is a methyixanthine used for the treatment of asthma. Intravenous infusions of aminophylline, the ethylenediamine salt of theophylline, are used to treat bronchospasm, congestive heart failure, and neonatal apnea. Theophylline is most commonly used orally in sustained-release preparations (eg, Theo-Dur , Slo-Phyllin, Theo-24 , and many others). 

A patient with chronic obstructive pulmonary disease had a 53% reduction in his serum theophylline levels accompanied by bronchospasm when he was fed continuously through a nasogastric tube with OsmoUte. The interaction occurred with both theophylline tablets (Theo-Dur) and liquid theophylline, but not when the theophylline was given intravenously as aminophylline. It was also found that the interaction could be avoided by interrupting feeding 1 hour either side of the oral liquid theophylline dose. Conversely, hourly administration of 100 mL of OsmoUte did not affect the extent of theophylline absorption from a slow-release preparation Slo-bid Gyrocaps) in healthy subjects, although the rate of absorption was slowed. Similarly, in healthy subjects, hourly administration of 100 mL of Ensure for 10 hours did not affect the rate or extent of absorption of theophylline from Theo-24 tablets. ... 

Similarly, no significant changes in serum theophylline levels were seen in 20 patients taking slow-release theophylline (Theo-dur) 300 mg twice daily, or intravenous theophylline 4 mg/kg three times daily, when they were given midecamycin diacetate (mioeamyein ponsinomycin) 1.2 g daily for 10 days. A number of other studies eonfirm the absence of a clinically important interaction between oral or intravenous theophylline or intravenous aminophylline and mideeamyein diaeetate in children and adults.25-28... 

---