The Spectrum of Lung Disease

Although less common than in WG, limg disease in MPA is associated with a poor clinical outcome. Those patients presenting with pulmonary hemorrhage have a significantly higher mortality than the whole MPA population (Fig. 3). 

Additional supportive treatment may also be required for example, in patients with alveolar hemorrhage, preventing fluid overload may prevent further pulmonary bleeding, ventilation in the prone position may improve oxygenation, and treatment with activated factor Vila may diminish bleeding from the capillaritis (56). 

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