The Role of Cell Surface Carbohydrates in Cancer

Cancer is the number one cause of death in developed countries. The cancer mor- 

Many studies have been carried out using anti-carbohydrate antibodies for cancer diagnosis. These studies reveal a correlation between particular carbohydrate antigens and poor clinical prognosis, including metastasis (88,90-92). Therefore, specific carbohydrate structures expressed on the cancer cell surface may play a role in metastasis. The section below describes two hypotheses on carbohydrate-dependent cancer metastasis by selectin-dependent and selectin-independent mechanisms. 

1H Fucat 2Gaipi 3GlcNAcpi 2H Fucat 2Gaipt 4GlcNAcpt  

Lea Gaipi 3GlcNAcpi 4 Fucat Le Gaipt 4GlcNAcpt 3 Fucat  

Leb Fucat 2Gaipt 3GlcNAcpt 4 Fucat Lev Fucat 2Galpt 4GlcNAcpt 3 Fucat  

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