Oxytricha nova

S. Haider, G.N. Parkinson and S. Neidle, Crystal structure of the potassium form of an Oxytricha nova G-quadruplex, J. Mol. Biol., 2002, 320, 189-200. 

The X-ray crystal structure at 1.86 A resolution of the Oxytricha nova telomere end binding protein (OnTEBP) in complex with DNA and in the presence of NaCl (PDB ID 1JB7) has also shown that d(G4T4G4) adopts a... 

Structural model of the complex of the 3,6,9-trisubstituted acridine ligand (3) with the intramolecular basket quadruplex structure of the human telomeric sequence, (a) End-stacking with the terminal G-tetradpermits the substituent at the 9-position to interact with the flexible TTA loop structure in a specific manner, (b) X-ray structure of the complex of a di-substituted aninoalkylamido acridine (4) with the dimeric hairpin quadruplex structure derived from the Oxytricha nova sequence d(GGGGTTTTGGGG)2. The drug end-stacks and interacts extensively with the thymine loop ((a) Adapted from ref 25 and (b) from RCSB Protein Data Bank co-ordinates ILIH (ref 49)). 

Subsequently, two X-ray structures have been reported one of a drug-bound dimeric anti-parallel G-quadruplex containing the Oxytricha nova sequence d(GGGGTTTTGGGG) in which a di-substituted aminoalkylamido acridine drug (4, see Figure 2) end-stacks with a terminal G-tetrad and interacts with one of the loops." In the other structure a daunomycin (14) trimer stacks on... 

M.P. Horvath and S.C. Schultz, DNA quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex, /. Mol. 

Two G-quadruplex structures have been reported. The G-quadruplex from Oxytricha nova has been reported using thaUium as the monovalent binding metal, containing five Tl(i) ions. The ohgonucleotide d(G4T3G4) forms a bimolecular... 

A Na solid-state NMR study of the bound sodium cations in a G-quad-ruplex formed by Oxytricha nova telomere DNA was shown. Using a 2D MQMAS Na NMR method, three sodium cations residing inside the quad-ruplex channel were observed. For comparison, solid-state N MAS NMR... 

---