The Lacuzong Case

As a part of the settlement, GlaxoSmithKline was allowed to keep secret its records, and I was not allowed to make public my findings. Because my findings were of grave public health significance, including my discovery that the company had manipulated data to minimize the threat 

An important issue in the Lacuzong case was the capacity of one, two, or three daily doses of Paxil 10 to cause severe mental disturbances. During my site visit to the offices of GSK, I combed through adverse drug reaction reports to determine how early in treatment they began. I discovered that the first few days were the greatest time of risk. 

My analysis of GSK s sealed documents confirmed that the company had hidden the true rate of suicidality by failing to report all suicide attempts on Paxil, by artificially inflating the number of suicides for patients taking placebo, and—in a fashion similar to Eli Lilly—by miscoding many suicides. The company had listed numerous suicide attempts under the relatively benign category of emotional lability (emotional 

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The section about the Lacuzong case draws on a similar section in my book Medication Madness (in press). 

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