The eukaryotic genome

Indeed, genome compartmentalization was not only found in warm-blooded, and to a smaller extent, in cold-blooded vertebrates, but also in other eukaryotes, ranging from trypanosomes to Drosophila. At least in some cases, this compartmentalization seemed also to be linked to the thermodynamic stability of DNA. 

Linear correlations were found between GC (and GC3) levels of genes and GC levels of the corresponding introns and flanking sequences. 

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The protein coding regions of DNA, the transcripts of which ultimately appear in the cytoplasm as single mRNA molecules, are usually interrupted in the eukaryotic genome by large intervening sequences of... 

Camacho, J.P.M. (2004) B Chromosomes in the Eukaryote Genome, 1st edn. Karger, Basel, Switzerland. 

Zuckerkandl E (2002) Why so many noncoding nucleotides The eukaryote genome as an epigenetic machine. Genetica 115 105-129... 

B. John and G. Miklos, The Eukaryote Genome in Development and Evolution, p. 150. Allen and Unwin, London, 1988. 

Because the bacterial genome is smaller in size than the eukaryotic genome, nonrepeated sequences in DNA from the former will be present at a higher concentration. Renaturation is a bimolecular reaction and will proceed more quickly when the reactants are at a higher concentration. 

Hannah SS and Norman AW (1994) 1 alpha, 25(OH)2 vitamin D3-regulated expression of the eukaryotic genome. Nutrition Reviews 52,376-82. 

Amaral PR EHnger ME, Mercer TR, Mattick JS (2008) The eukaryotic genome as an RNA machine. Science 319 1787—1789... 

In contrast, Penny and Poole (1999) suggested that the last universal common ancestor may have been a mesophile with many features of the eukaryote genome, and the first distinct eukaryote may thus also have been mesophile—a distal inhabitant of a hydrothermal system, or a planktonic form. 

There are also relatively short, repetitive DNA sequences dispersed throughout the eukaryotic genome that do not code for proteins (e.g., Alu sequences). 

Shahmuridov K. A., Kolchanov N. A., Solovyev V. V., Ratner V. A. (1986) Enhancer-like structures in middle repetitive sequences of the eukaryotic genomes. Genetics (Russ.), 22, 357-368. 

Amaral, P. P., Dinger, M. E., Mercer, T. R., Mattick, J. S. (2008). The eukaryotic genome as an RNA machine. Science. 319 1787—1789. American Academy of Pediatrics. (2005). Policy statement. Lead exposure in children prevention, detection, and management. Pediatrics. 116 1036—1046. 

See also Protein Targeting, Size of the Eukaryotic Genome, Gene Amplification (from Chapter 25)... 

Adam C. Bell, Adam G. West, Gary Felsenfeld, Insulators and Boundaries Versatile Regulatory Elements in the Eukaryotic Genome, Science, 291 (2001), 447 50. 

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