The Development of Parallel Procedures

The authors constructed an 80-well hydrogenator. Fifteen catalysts were screened and the isotopic incorporation assessed by LC-MS. The regiospecificity was determined by VAST Direct Injection NMR [99] in conjunction with SPADEZ [100], a multi-spectrum analysis tool - this is capable of displaying and quantifying up to 96 spectra. So far it has not been possible to vary the solvents as, under the experimental conditions, the more volatile distil over into the less volatile solvents. 

Reaction conditions DCOOK/D O, DMSO, level (II) of 750W, 40 sec 

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