The Cannabidiol Story

The widely varying effects of marijuana and hashish have long 

J -Tetrahydrocannabivarol Cannabivarol (tetrahydrocannabidivarol, (cannabidivarol, tetrahydrocannabivarin, propyl-THC) 

Geranyl pyrophosphate R = H, Olivetol R = COOH, Oliveiolic acid 

The effects of CBD on the THC high need further investigation, however. It is possible that when present in large amounts, CBD is involved in some of the interesting and pleasurable aspects of the high. It may well be that marijuana that has lots of CBD and THC can be more desirable than that with THC alone. This may be why hashish, though it normally has much less THC 

This could also explain some of the striking differences in subjective experience afforded by different marijuana. As the CBD content increases relative to that of THC, the high will be weakened and delayed. Thus, g ass which has an adequate THC content (say 1%) but s nificant amounts of CBD (say 0.5%) will tend to be very mild, but will slowly creep up on the user and may have him more stoned four hours later than if there were no CBD present. Sometimes this is advantageous in a recent experiment naive subjects reported that joints containing CBD with THC were more pleasant chan with THC alone. The CBD attenuated the high enough to rid them of anxiety and the jitters.  

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To summarize, the cannabidiol story is confusing because of the complex nature of its interactions with THC and because relatively little research has been done. Meanwhile, it seems reasonable to assume that as CBD content approaches that of THC, the high will be diminished in intensity, but prolonged. 

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