The Betaherpesviridae Subfamily

Unknown Immune system escape downregu-lates MHC Class I and PKC Homeostasis and cellular trafficking heterodimerizes with a variety of human chemokine receptors in B cells  

Atherosclerosis mediates smooth  

HHV-7 U12 CX3CR1 CCL17, CCL19, CCL21, CCL22 Viral life important for viral replication, induction of cytopathic effects and can enhance cell-cell fusion in infected cells Unknown 

HHV-6 and HHV-7 from the Rh olovirus genus present a high distribution worldwide with infection rates of respectively 70-100% and 75% (7,8]. Primary infection with HHV-6 results in the development of exanthema subitum and can lead to complications such as malaise, febrile seizures and in some rare cases encephalitis [7]. HHV-6 is heavily associated with diseases of the central nervous system in immunocompromised patients such as encephalitis and/or encephalopathy 7], but also with multiple sclerosis. In particular, anti-HHV-6 antibodies and HHV-6 DNA have been detected in MS cerebrospinal fluid and MS plaques, respectively [9]. So far, the link of HHV-7 and diseases other than exanthema subitum during primary infection remains highly speculative 9-11]. Additional studies are required to understand the true contribution of HHV-7 in pathological conditions. 

Herpesviruses Encode Constitutively Achve Viral Chemokine Receptors 

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