Tetrazole 5-thio

Tetrazole, l-(p-substituted phenyl)-antimicrobial activity, 5, 835 Tetrazole, 5-thio-rearrangements, 5, 823 Tetrazole, 2-thioacyl-reactions, 5, 109 Tetrazole, 5-(o-tolyl)-tautomerism, 5, 804 Tetrazole, 5-(p-tolyl)-dipole moments, 5, 795 tautomerism, 5, 804 Tetrazole, 5-(trimethylsilylamino)-synthesis, 5, 832 Tefrazolecarbaldehydes reactions, 5, 820 Tetrazole-5-carbaldehydes reactions, 5, 820 Tetrazolecarbonitriles reactions, 5, 820 Tetrazole carbonyl compounds reactions, 5, 820 Tetrazolecarboxylic acid, 5-aryl-acidity, 5, 816... 

MNDO calculations have been reported that compare PhS [58], pyridyl-2-thio-radical [58], A-oxypyridyl-2-thioradical [59], and a tetrazole thio radical [60]. Relative experimental reactivities were found to correlate imperfectly with the calculated spin populations, but more reliably with the calculated SOMO energies. 

Chemical Name (6R-trans)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)thio] methyl)-8-oxo-7-([(1-H-tetrazol-1 -yl)acetyl] amino)-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid sodium salt... 

CN [6R-[6a,7p(/J )]]-7-[(hydroxyphenylacetyl)amino]-3-[[(l-methyl-l//-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid... 

A series of diastereomerically pure 5 -0-DMT-nucleoside 3 -0-(2-thio-l,3,2-oxathiaphospholanes) and their oxathiaphospholane ring-substituted analogues 283-294 were isolated in 80-83% yield by column chromatography on silica gel of the appropriate diastereomeric mixtures [the ratio ca 55 45 (31P NMR assay)] obtained from the reaction of 2 - A, IV- dii so p rop y I a m i n o- 1,3,2-oxathiaphospholane 279-281 with 5 - 0 -D M T- n uc I cosides 282a-d in the presence of tetrazole (phosphi-tylation), followed by addition of sulfur (Scheme 67) [105-107]. 

Ceforanide Ceforanide, (6R, 7R)-7[2-(a-amino-o-tolyl)acetamido]-3-[[[l-carboxymethyl-17/-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (32.1.2.27), is also structurally related to cefamandole, differing in that the acylating acid was o-aminomethylphenylacetic acid, and also in the presence of a carboxyl group in the methyl substituent of the tetrazol ring. It is also synthesized by methods analogous to the synthesis of cefamandole [124-128]. 

OXOETHYHDENEl-l,3-OITHIETAN-2-YLICARBONYLlAMIN01-7-HETHOXY-3-<-Kl-METHYL-IH-TETRAZOL- 5-YL (THIO(METHYL (-S-0X0-,... 

Moxalactam disodium is a drug entity which was discovered at Shionogi and Company, Limited, Osaka, Japan, and codeveloped with Eli Lilly and Company. The drug is marketed under the trade names of MOXAM and LAMOXAM . The chemical entity is the disodium salt of (6R,7R)-7-[[carboxy(4-hydroxy-phenyl)-acetyl]amino]-7-methoxy-3-[[l-methyl-lH-tetrazole-5-yl)thio]-methyl]-8-oxo-5-oxa-l-azabi cyclo[4.2.0]oct-2-ene-2-carboxyli c acid. 

Figure 6 shows a typical chromatogram obtained from such a procedure. In this chromatogram, the elution of the thio-tetrazole, the R and S isomers of moxalactam, and the moxa-lactam decarboxylated product are shown. In this test for other related substances, only those substances which are not dealt with by specific tests are considered. Quantitative information is obtained by summing the response for all the extraneous peaks and comparing them to the sum of the response for the R and S isomers of a diluted moxalactam reference standard. The assumption is made that all of these materials have similar spectral response characteristics at 254 nm. 

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