Tetrahydrocannabinol , effect

Cutler MG, Mackintosh JH. (1984). Cannabis and delta-9-tetrahydrocannabinol. Effects on elements of social behaviour in mice. Neuropharmacology. 23(9) 1091-97. 

Dimethylheptyl-delta-6 a 1 Oa-tetrahydrocannabinol effects after parenteral administration to man. Proc. Soc. Exp. Biol. 

Sidell FR, Pless JE, Neitlich H et al. Dimethylheptyl-delta-6al0a-tetrahydrocannabinol effects after parenteral... 

Muchtar, S., et al. 1992. A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol Effect on intraocular pressure in rabbits. Ophthalmic Res 24 142. 

D Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in... 

A great advantage of catalyst 24b compared with other chiral Lewis acids is that it tolerates the presence of ester, amine, and thioether functionalities. Dienes substituted at the 1-position by alkyl, aryl, oxygen, nitrogen, or sulfur all participate effectively in the present asymmetric Diels-Alder reaction, giving adducts in over 90% ee. The reaction of l-acetoxy-3-methylbutadiene and acryloyloxazolidinone catalyzed by copper reagent 24b, affords the cycloadduct in 98% ee. The first total synthesis of ewt-J -tetrahydrocannabinol was achieved using the functionalized cycloadduct obtained [23, 33e] (Scheme 1.39). 

Group of compounds which naturally occur in the hemp plant, Cannabis saiiva. Most of them are unsoluble in water. The most abundant cannabinoids are A9--tetrahydrocannabinol (THC), its precursor cannabidiol and cannabinol, which is formed spontaneously from THC. Cannabinoids exert their effects through G-protein coupled cannabinoid receptors (CBi/CB2). 

Dronabinol (tetrahydrocannabinol), the active principle from cannabis and synthetic cannabinoids, nabilone and levonantradol are effective in treating nausea and vomiting in cancer chemotherapy. The mode of action is unclear but appears to involve cannabinoid CBi receptors. Cannabinoids have been shown to reduce acetylcholine release in the cortex and hippocampus, and have been suggested to inhibit medullary activity by a cortical action. Inhibition of prostaglandin synthesis and release of endorphins may also be involved in the antiemetic effect. A review of trials of dronabinol, nabilone or levonantradol concluded that while the cannabinoids were superior to placebo or dopamine receptor antagonists in controlling emesis... 

Wachtel SR, El Sohly MA, Ross SA, et al Comparison of the subjective effects of deltaO-tetrahydrocannabinol and marijuana in humans. Psychopharmacology... 

Sim LJ, Hampson RE, Deadwyler SA, Childers SR. Effects of chronic treatment with delta-9-tetrahydrocannabinol on cannabinoid-stimulated [35S]GTPgamma-S autoradiography in rat brain. J Neurosci 1996 16 8057-8066. 

Hollister LE, HK, G. The benzodiazepine receptor antagonist flumazenil does not block clinical effects of delta-9-tetrahydrocannabinol. Life Sci 1990 47 1655-1650. 

Bloom, A.S., Effect of delta-9-tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes, J. Pharmacol. Exp. Ther., 221, 97, 1982. 

Hershkowitz, M. and Szechtman, H., Pretreatment with A1 tetrahydrocannabinol and psychoactive drugs effects on uptake of biogenic amines and on behavior, Eur. J. Pharm., 59, 267, 1979. 

Wu, X. and French, E.D., Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons an electrophysiological assessment, Neuropharmacology, 39, 391, 2000. 

Kupfer D, Levin E and Burstein SH (1973). Studies on the effects of tetrahydrocannabinol and ddt on the hepatic microsomal metabolism of the and other compounds in the rat. Chemical-Biological Interactions, 6, 59-66. 

Raft D, Gregg J and Ghiaj Harris L (1977). Effects of intravenous tetrahydrocannabinol on experimental and surgical pain Psychological correlates of the analgesic response. Clinical Pharmacology and Therapeutics, 21, 26-33. 

Marijuana (reefer, pot, grass, weed) is the most commonly used illicit drug. The principal psychoactive component is A9-tetrahydrocannabinol (THC). Hashish, the dried resin of the top of the plant, is more potent than the plant itself. Pharmacologic effects begin immediately and last 1 to 3 hours. 

Cabral, G.A. et al., Effect of delta 9-tetrahydrocannabinol on herpes simplex virus type 2 vaginal infection in the guinea pig, Proc. Soc. Exp. Biol. Med., 182, 181, 1986. 

Gallager, D. W., Sanders-Bush, E., and Sulser, F. (1972) Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following A -tetrahydrocannabinol. Psychopharmacology, 26 337-345. 

Several products are derived from the cannabis plant (table 10.1). Hashish and charas are the dried resin exuded from the female flowers. These have the highest content of A9-tetrahydrocannabinol (TFIC) at 10-20% and have the most potent psychoactive effects. Ganja and sinsemilla are the dried tops of the female plants, which averages 5-8%. Marijuana and bhang are derived from the rest of the plant and have the lowest TFIC concentration (2-5%). 

Moss DE, Johnson RL. (1980). Tonic analgesic effects of delta 9-tetrahydrocannabinol as measured with the formalin test. EurJ Pharmacol. Feb. 8 61(3) 313-15. 

Belgrave BE, Bird KD, Chesher GB, Jackson DM, Lubbe KE, Starmer GA, Teo RK. (1979). The effect of (—) trans-delta9-tetrahydrocannabinol, alone and in combination with ethanol, on human performance. Psychopharmacology (Berlin). 62(1) 53-60. 

Cooler P, Gregg M. (1977). Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. Southern Med J. 70(8) 951-54. 

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