Tetracyclines Diuretics

TETRACYCLINES DIURETICS Possible risk of renal toxicity Additive effect Some recommend avoiding coadministration others advise monitoring renal function closely. Doxycydine is likely to be less of a problem... 

The effects of warfarin may increase when administered with acetaminophen, NSAIDs, beta blockers, disulfiram, isoniazid, chloral hydrate, loop diuretics, aminoglycosides, cimetidine, tetracyclines, and cephalosporins. Oral contraceptives, ascorbic acid, barbiturates, diuretics, and vitamin K decrease the effects of warfarin. Because die effects of warfarin are influenced by many drugp, die patient must notify die nurse or die primary healdi care provider when taking a new drug or discontinuing... 

A few important drugs, namely thiazide diuretics (e.g., chlorothiazide, hydroflumethiazide, bendroflumethiazide, benzthiazide, cyclothiazide etc.), neomycin, tetracyclines, methyldopa etc., help in enhancing the BUN levels perhaps due to interference with normal renal function,... 

Drugs that may affect ACEIs may include antacids, capsaicin, indomethacin, phenothiazines, probenecid, and rifampin. Drugs that may be affected by ACEIs include allopurinol, digoxin, lithium, potassium preparations/potassium-sparing diuretics, and tetracycline. 

Drugs that may affect penicillins include allopurinol, aminoglycosides (parenteral), aspirin, beta blockers, chloramphenicol, erythromycin, ethacrynic acid, furosemide, indomethacin, phenylbutazone, probenecid, sulfonamides, tetracycline, and thiazide diuretics. Drugs that may be affected by penicillins include aminoglycosides (parenteral), anticoagulants, beta blockers, chloramphenicol, cyclosporine, oral contraceptives, erythromycin, heparin, and vecuronium. 

Uses Infxns of resp tract, skin/soft tissue, scarlet fevCT, S5 philis Action Bactericidal -1- cell wall synth Dose Adults. 0.6-4.8 million Units/d in doses ql2-24h give probenecid at least 30 min prior to PCN to prolong action Feds. 25,000-50,000 Units/kg/d IM daily-bid Caution [B, M] Contra AU gy Disp Inj SE Pain at inj site, int stitial n hritis, anaphylaxis Interactions t Effects W/probenecid t penicillin 1/2-life Wf ASA, furosemide, indomethacin, sulfonamides, thiazide diuretics T risk of bleeding W/ anticoagulants -1- effects Wf chloramphenicol, macrolides, tetracyclines -1- effects OF OCPs EMS See Penicillin G, Aqueous OD See Penicillin G, Aqueous... 

Renal tubular acidosis and other renal injury resulting in nitrogen retention have been attributed to the administration of outdated tetracycline preparations. Tetracyclines given along with diuretics may produce nitrogen retention. Tetracyclines other... 

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