Toxicity additive effect

LOOP DIURETICS TETRACYCLINES Possible risk of renal toxicity Additive effect Some recommend avoiding co-administration others advise monitoring renal function closely. Doxycydine is likely to be less of a problem... 

LOOP DIURETICS VANCOMYCIN Risk of renal toxicity Additive effect Monitor renal function closely... 

VALPROATE ANTIPSYCHOTICS -OLANZAPINE Risk of bone marrow toxicity Additive effect Monitor FBC closely warn patients to report sore throat, fever, etc. 

CLOZAPINE CHLORAMPHENICOL, SULPHONAMIDES t risk of bone marrow toxicity Additive effect Avoid co-administration... 

RETINOIDS VITAMIN A Risk of vitamin A toxicity Additive effect tretinoin is a form of vitamin A Avoid co-administration... 

RIFAMPICIN QUINUPRISTIN/ DALFOPRISTIN Risk of hepatic toxicity Additive effect Monitor LFTs closely... 

Liver function is often abnormal in chronic inhalant abusers. After abstinence, function usually returns to normal, but if the individual returns to inhalant use, the problems will return. When inhalant use is coupled with alcohol abuse, which also causes liver toxicity, additive effects may occur. 

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