1,3,5,7-Tetraazatricyclo decane

Tetramethylenedisulfotetramine Tetramethylenedisulfotetramine (TETS, tetramine, CAS No. 80-12-6, 2,6-dithia-l,3,5,7-tetraazatricyclo[3.3.1.13,7]-decane,2,2,6,6-tetraoxide) is emerging as an ilhcit neurotoxin (Barrueto et al, 2003 Whitlow et al, 2005). Tetramine is an odorless white crystalline power that is radially soluble in water, mixes with feedstuffs, and is generally considered to be tasteless. The mechanism of action for TETS is that it selectively and irreversibly binds... 

Although several workers have studied the reaction of hexamethylenetetramine (hmt l,3,5,7-tetraazatricyclo[3.3.1.13.7]decane) with phosgene, the product has never been fully characterized, despite its alleged importance as a prophylactic agent in phosgene poisoning (Section 2.6). 

Strucmrally related, superbasic proton sponges have been designed by Estrada [24]. A minimal framework was provided by the stmctures of 3,6,7,8-tetraazatricyclo[3.1.1.1 ] octane (26) and 4,8,9,10-tetraazatricyclo[5.1.1.1 ]decane (30). These molecules, possessing two pairs of nitrogen atoms fixed in a configuration where two nitrogen atoms are in... 

Synonyms Aminoform Ammonioformaldehyde Hexa Hexamethylena-mine Hexamethyleneamine Hexamethylenetetraamine Hexamine HMT HMTA Methamin Methenamine (INCI) 1,3,5,7-Tetraazaadaman-tane 1,3,5,7-Tetraazatricyclo [3,3,1,1] decane Urotropine ClassiFication Organic amine Empirical CsHijN,... 

Tetraazatricyclo [3,3,1,1] decane. See Hexamethylenetetramine Tetrabasic lead fumarate. See Lead fumarate tetrabasic... 

Tertiary amines [70], some inorganic salts [71], ammonia [70], and l,3,5,7-tetraazatricyclo[3.3.3.P ]decane (hexamethylenetetramine) [72] can catalyze the formation of resoles. The basic pH in the reaction mixture produees a phenolate anion. This anion possesses a higher electron density at the ortho and para positions. Therefore, the electrophilic attack of the carbon end of the methanal occurs more efficiently in these positions. Furthermore, the dehydration of the hydroxymethylol group oecurs slower because the cation of the basic catalyst stabilizes the hydroxymethylated phenols. A typical example for such a stabilized structure is given in Seheme 3. 

The compound l,3,5,7-Tetraazatricyclo[3.3.3.P- ]decane is a crosslinking agent for novolacs of great importance for over a decade. 1,3,5,7-Tetraazatricyclo-[3.3.3. H ]decane is prepared from methanal and ammonia according to the equilibrium reaction described in equation 17. 

The best overall performance is obtained by mixing 9 to 10 weight percent l,3,5,7-tetraazatricyclo[3.3.3.P ]decane into a novolac that is prepared using a ratio of phenol to paraformaldehyde of 1 0.8. Equations 18 to 21 show a... 

Novolacs can be transformed into insoluble, nomnelting, thermally stable fheimosets by crosslinking reaction with 1,3,5,7-tetraazatricyclo-[3.3.3. H ]-decane (hexamethylenetetramine), oxiiane (epoxides), diisocyanates, urea. 

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