Terminal segment

Waals interactions with the PI Cys, and also located basic Arg and Lys residues in position to interact with the P6 acidic residue. More detail of the binding of the N-terminal (i.e., P residues) part of the substrate was subsequently inferred from NMR studies showing a p-sheet interaction between this N-terminal segment of the substrate and enzyme largely confined to within the C-terminal p-barrel (Cicero et al. 1999). 

Gordon, L.M., Lee, K.Y.C., Lipp, M.M., Zasadzinski, J.A., Walther, F.J., Sherman, M. A., and Waring, A.J. Conformational mapping of the N-terminal segment of surfactant protein B in lipid using C-13-enhanced Fourier transform infrared spectroscopy. J. Peptide Res. 

Barhanin et al. (26) chemically modified the side chains of several residues to correlate structure and function in As II. Their results established the importance of charged residues for the function of the toxin. They showed that Arg-13 is essential for binding to the sodium channels as well as for toxicity, while the aspartate, glutamate, and lysine residues in the N-terminal segment of the protein are... 

In aqueous buffer, pardaxin is comprised of four antiparallel monomers tightly packed with 2-fold symmetry of the "4-4 ridges into grooves" type the hydro-phobic amino-terminal segments of pardaxin monomers are shielded from the aqueous surface in the tetramer which most probably exposes the polar side chain to water. 

The assignment of the six additional transmembrane helices (M5-M10) is less conclusive. Since both the N-terminal and the C-terminal segments of the Ca " -ATPase molecule are exposed on the cytoplasmic surface of the membrane [112,135-138], the number of transmembrane sequences must be even, probably eight or ten odd numbered transmembrane domains (seven or nine) appear to be excluded [138,139]. 

Brace NO (1962) Long chain alkanoic and alenoic acids with perfluoroalkyl terminal segments. J OrgChem 40 4491 1493... 

For type II membrane proteins, in which their N-terminal segment is exposed at the cytosolic side, the signal was found on their N terminus. There are relatively few type II proteins in the ER. This time, a diarginine motif, XXRR, is important. Its variations include XRR, XXXRR, XRXR, and XXRXR. The replacement of R with K may be allowed in some cases. 

Fig. 10.4. HsIVU activation mechanism. (A) Stereo view (C -trace) of the superposition of the C-domain of an HsIU subunit (red) from the original E. coli HsIVU complex onto that of the H. influenzae HsIU subunit (green) from its complex Two HsIV subunits (pink and blue) from the H. influenzae complex are also shown to illustrate the binding of the C-terminal segment of H. influenzae HsIU to the pocket between the HsIV subunits (indicated also by a...

The current hypothesis for the role of the leader peptide in dehydratase activity and processivity is shown in Figure 8 and is based on the results from several studies. LctM is proposed to recognize a certain secondary structure, possibly helical (see Section 5.08.3.2), adopted by the C-terminal segment of the leader peptide. Leader peptide binding is then postulated to bring the structural region of the substrate in close proximity to... 

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