Tenuazonic acid antiviral activity

Tenuazonic acid has a broad toxicity spectrum and is regarded as a mycotoxin [28]. It was first detected as a growth inhibitor of tumour cells (human adenocarcinoma), and was later shown to have weak antibacterial and, at high dose levels (100-500 p,g/ml), antiviral activity towards poliovirus MEF-1, enterovirus (ECHO-9), respiratory viruses (parainfluenza-3), vaccinia and Herpes simplex (HF). It has been shown to be an inhibitor of peptide bond formation in preventing substrate binding to acceptor site of peptidyltransferase in human ribosomes [29]. 

Tenuazonic acid (741) is also of great interest since it is considered to exhibit the greatest toxicity among the Alternaria mycotoxins. It exhibits phytotoxic, insecticidal, zootoxic, cytotoxic, antibacterial, antitumor, and antiviral activities 489, 490). Furthermore, 741 might be the causal factor of onyalai, a hematological disorder in man 491). 

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