Templating techniques interactions

The following two synthetic techniques are applied for obtaining complexes of aliphatic, aromatic, and heterocyclic imines in the limits of the discussed variant of the template synthesis interaction of coordinated mono- and diamines with mono- and dicarbonyl derivatives (method A) and reactions of complexes of o-hydroxyalde-hydes (ketones) with amines and diamines (method B). The simplest transformation of this type is represented by the reaction (3.176) [53,54] ... 

The use of templates supported on polymer beads can become a very useful tool for the development of synthetic receptors through the dynamic combinatorial approach. Since the template is attached to a solid support, the untemplated species will eventually become washed from the solid support by filtration leaving only strong binders appended to the beads. The species attached to the solid phase may be washed off under different solvent conditions that disrupt the template-receptor interaction and subsequently identified. The development of selection techniques using guests appended to polymer beads is pivotal to the management and success of highly diverse DCLs of receptors. 

Hence zeolite synthesis shares some of the same combinatorial self organization and self learning aspects as seen in the antibody system. During zeolite crystallization template molecules are incorporated in unique positions. Molecular mechanics techniques have been developed ] that allow the prediction of optimum template zeohte interaction useful to select template molecules to synthesize preselected zeohte structmes. 

Some limitations of this molecular imprinting technique are obvious the template must be available in preparative amounts, it must be soluble in the monomer mixture and it must be stable and unreactive under the conditions of the polymerization. The solvent must be chosen considering the stability of the monomer-template assemblies and it should result in the porous structure necessary for rapid kinetics of the template interaction with the binding sites. If these criteria are satisfied, a robust material capable of selectively rebinding the template can be easily prepared and evaluated in a short period of time. 

Another technique which is used to follow the extent of template polymerization vs. time is turbidimetry. Two types of measurements can be used here. The first is based on the determination of passed light intensity, the second on the determination of scattered light intensity. The former was used in many papers by Ferguson and co-workers for studies on polymerization of acrylic acid in aqueous solution in the presence of many homopolymers used as templates as well as for application of copolymers with interacting and non-interacting groups. This measurement was also used for studying com-... 

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