Technetium Tc 99m bicisate

Molecular formula Ci2H2iN205S Tc Molecular weight 436.44 CAS Registry No 121281-41-2 Merck Index 13,9181 

Mobile phase Gradient. MeCN 50 mM ammonium acetate (unspecified) Flow rate 1 

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Neurolite (for preparation of technetium Tc 99m bicisate injection) — vial Aa OctreoScan (for preparation of indium In 111 pentetreotide injection) — reaction vialb UltraTag RBC (for preparation of technetium Tc 99m red blood cells injection) — syringe l°... 

Technetium ( Tcj Bicisate Injection. A sterile colorless solution of bicisate is complexed with Tc-99m pertech-neuite after reduction with a stannous salt. The precise structure of the technetium complex is fN,N -ethylene-di-L-cy.steinato(3-) oxo "Tc]technetium(V) diethyl ester. This radiopharmaceutical is a neutral and lipophilic complex that crosses the blotxl-brain barrier and is selectively retained in the brain. Therefore, this radiotracer is used as a brain-perfusion imaging agent. After intravenous injection of 20 mCi (740 MBq) of Tc-99m bicisate, about 5% of the injected dose is localized within the brain cells 5 minutes after injection and demonstrates rapid renal excretion (74% in 24 hours). This radiotracer is used clinically to evaluate dementia, stroke, lack of brain perfusion ("brain death"), cerebral vascular reserve, or risk of stroke (acetazolamide challenge. study) and to localize a seizure focus for surgical removal. 

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