Technetium Tc

Gmelin Handbook of Inorganic Chemistry Tc, Technetium, 8th ed., Suppl. Vol. 1. Springer-Verlag, Berlin, 1982 Suppl. Vol. 2. Springer-Verlag, Berlin, 1983. 

Technetium ( Tcj Bicisate Injection. A sterile colorless solution of bicisate is complexed with Tc-99m pertech-neuite after reduction with a stannous salt. The precise structure of the technetium complex is fN,N -ethylene-di-L-cy.steinato(3-) oxo "Tc]technetium(V) diethyl ester. This radiopharmaceutical is a neutral and lipophilic complex that crosses the blotxl-brain barrier and is selectively retained in the brain. Therefore, this radiotracer is used as a brain-perfusion imaging agent. After intravenous injection of 20 mCi (740 MBq) of Tc-99m bicisate, about 5% of the injected dose is localized within the brain cells 5 minutes after injection and demonstrates rapid renal excretion (74% in 24 hours). This radiotracer is used clinically to evaluate dementia, stroke, lack of brain perfusion ("brain death"), cerebral vascular reserve, or risk of stroke (acetazolamide challenge. study) and to localize a seizure focus for surgical removal. 

Rb Rubidium 37 Sr Strontium 38 Iff Y Yitrium 39 Zr Zirconium 40 Nb Niobium 41 Mo Molybdenum 42 Tc Technetium 43 Ru Ruthenium irfiN Rh Rhodium 45... 

Tc technetium, 43, 1937 from the Greek "technetos (artificial) because it was the first artificial element. 

Y ytterbium 40 Zr zirconium 41 Nb niobium 42 MO molybdenum 43 TC technetium 44 Ru ruthenium 45 Rh rhodium 46 Pd palladium 47 Ag silver 48 Cd cadmium... 

System I Gelman ITLC silica gel fiberglass plates and 2-butanone (methyl ethyl ketone [MEK]) as solvent Reduced, hydrolized Tc-technetium (C) and the secondary Tc-HMPAO complex (A) remain at the start (A-tC) the lipophilic Tc-HMPAO complex (D) and unbound Tc-Na-pertechnetate (B) are measured at the solvent front (B+D). 

System I Gelman ITLC-SG fiberglass plates and MAM as solvent Rednced, hydro-lized Tc-technetium is measnred at the start (A) Tc-depreotide and free 99mTc-Na-pertechnetate as well as the " Tc complexes (glnceptate and edetate) move with the solvent front. 

---