Tcell dendritic cell

Psoriasis is an inflammatory skin disease characterized by red, scaly, raised plaques. Usually, the psoriasis lesions are several centimeters in diameter and separated by normal-appearing skin [239, 240]. Psoriasis involves a chronic cutaneous pathologic process, driven by interactions between infiltrating leukocytes (Tcells, dendritic cells, macrophages, neutrophils), cytokines, chemokines and keratinocytes, the cells from the epidermis. The disease is initiated or exacerbated by infections, physical and/or emotional stress, antigenic stimuli and various medications (e.g., lithium, P-block-ers [241, 243]). Psoriatic plaques can revert back to symptomless skin spontaneously or after treatment vdth selective immune-targeted agents [239, 240, 242-244]. 

In vitro, MDC is chemotactic for a number of cell types including thymocytes (Cambell et al., 1999 Chantry et al., 1999), dendritic cells, monocytes, IL-2-activated NK cells (Godiska et al., 1997), TH2 T cells (Bonecchi et al., 1998 Sallusto et al., 1998 Imai et al, 1998) and CLA + Tcells (Cambell et al, 1999). MDC has also been reported to inhibit HIV replication in vitro (Pal et al, 1997 Struyf et al, 1999), although the physiological significance of this observation is still unclear. 

Neutro neutrophils eosino eosinophils baso basophils mono monocytes m4> macrophages DC dendritic cells pDC plasmoid dendritic cells mDC myeloid dendritic cells Th cell Thelper cells Treg cells regulatory Tcells fibro fibroblasten NK cells natural killer cells MC mast cells (4,5, 11, 15-18, 37-40],... 

In general, CXC chemokines are attractants for neutrophils and T lymphocytes and ELR-CXC chemokines are attractants for B and T lymphocytes (Table 6.1). CC chemokines induce chemotaxis of multiple subsets of white blood cells, such as monocytes, basophils, dendritic cells, macrophages, NK cells and Tcells (Table 6.2). C chemokines are important for T cells traveling to the thymus and the CX3C chemokine, fractalkine, also acting as an adhesion molecule, seems to be important for the infiltration of T cells, NK cells and monocytes (Table 6.3). 

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