Taurodeoxycholic acid

TDCA taurodeoxycholic acid, TCDCA taurochenodeoxycholic acid,... 

FIGURE 9 Electropherograms of the chiral resolution of (I) l-cyanobenz[/]isoindole (CBI)-selenomethionine and (II) CBI-selenoethionine enantiomers using a mixture of boric acid (10 mM) and phosphate buffer (30 mM, pH 7) as the mobile phase containing [i-cyclodextrin (30 mM) and taurodeoxycholic acid (50 mM) as CMPAs with sodium dodecyl sulfate (50 mM) as the mobile phase modifier (from Ref. 97). 

Taurolihtocholic acid (TLCA) Taurodeoxycholic acid (TDCA) Taurocholic acid (TCA)... 

Taurodeoxycholic acid sodium salt monohydrate (3ct, 12a-dihydroxy-5p-cholestan-24-oic acid V-(2-sulfoethyl) amide Na salt monohydrate, iV-[desoxycholyl)taurine Na salt H2O)... 

The specificity of the inhibitory effect of bile acids on bile acid formation has been studied by Danielsson [110]. Taurocholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid, fed at the 1% level in the diet for 3-7 days, were found to inhibit cholesterol 7a-hydroxylase activity. Feeding taurohyodeoxycholic acid and... 

Prepare 100 ng/(J.l solutions of taurocholic acid, glycocholic acid, taurocheno-deoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, glyco-deoxycholic acid, and glycolithocholic acid (Sigma) in methanol. 

The approximate Rf values and order of migration should be as follows glycoli-thocholic acid, 0.10 glycodeoxycholic acid, 0.17 glycochenodeoxycholic acid, 0.20 taurodeoxycholic acid, 0.23 taurochenodeoxycholic acid, 0.26 glycocholic acid, 0.31 and taurocholic acid, 0.38. 

Such interactions are directly relevant to the effect of surfactants on drug absorption. Fig. 10.5a shows the relationship between absorption of salicylate or L-valine across rat jejunal tissue in vivo and release of protein and phospholipid by a series of surfactants. Fig. 10.5b shows the relative activity of a series of non-ionic surfactants of the Brij series and sodium taurodeoxycholic acid (NaTDC), sodium dodecyl sulphate (NaDS) and CTAB [30]. An association between protein release and increased absorption of solutes has also been reported by Feldman and Reinhard [31] and Walters et al. [32]. Anionic, non-ionic and cationic surfactants tended to accelerate the breakdown of the mucous layer covering the epithelium and at high concentrations were thought to interfere with the structure of the mucosal surface itself. Exposure of various anionic and nonionic surfactants to rabbit intestinal mucosa causes epithelial desquamation and necrosis [33]. 

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