Targets molecular mechanisms

Drug Targets Molecular Mechanisms of Drug Action 53... 

One target type for which the molecular mechanism of efficacy has been partly elucidated is the G-protein-coupled receptor (GPCR). It is known that activation of GPCRs leads to an interaction of the receptor with separate membrane G-proteins to cause dissociation of the G-protein subunits and subsequent activation of effectors (see Chapter 2). For the purposes of binding, this process can lead to an aberration in the binding reaction as perceived in experimental binding studies. Specifically, the activation of the receptor with subsequent binding of that... 

Global hazards can be mitigated through targeted molecular design. Uncovering the mechanism of ozone reduction by chlorine, and specifically by chlorofluorocarbons, has led to research chemicals that had minimal impact on stratospheric ozone. 

Ribeiro S, Horuk R. Chemokine receptor antagonists from the bench to the clinic. In Hannan A, Engelhardt B, eds. Leukocyte Trafficking-Molecular mechanism, therapeutic targets, and methods. Weinheim Wiley-VCH 2005 371 402. 

Animals cannot synthesize carotenoids de novo. To deposit carotenoids in the proper tissues in the proper amounts, they must acquire carotenoids from dietary sources and transport them to target sites. Knowledge of the molecular mechanisms of carotenoid transport, however, is still... 

Niles, L. P. (2006). Molecular mechanisms of melatonin action Targets in sleep... 

Rudnick, G. and Wall, S.C., The molecular mechanism of ecstasy [3,4-methylenedioxy-metham-phetamine (MDMA)] serotonin transporters are targets for MDMA-induced serotonin release, Proc. Natl. Acad. Sci. U.S.A. 89(5), 1817-1821, 1992. 

---