Molecular target, identification

Conley, P. B., Jantzen, H. M., Vincent, D., et al. (2000) Molecular identification of the platelet ADP receptor targeted by antithrombotic drugs. Blood. 96, 222A. 

Foster CJ, Prosser DM, Agans JM, et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001 107 1591-1598. 

The molecular identification of a plethora of T-cell tumor antigens that can serve as targets for many human cancers,... 

An advantage of NMR-based biomarker targeting is that it does not require any separation methods and thus we can use more complex mixtures. But this advantage brings with it a challenge it can be difficult to identify the compounds in the complex NMR spectrum. A limitation is that NMR, especially 1D-NMR, alone usually yields partial structures even for a pure compound. 2D-NMR gives more information and resolution for structure analysis, but its lower sensitivity is a disadvantage. Complete molecular identification often requires a combination of approaches. 

The molecular identification of several of the key enzymes of sphingolipid metabolism and some of their molecular targets has also allowed for the... 

LMMS results are frequently interpreted as a yes-or-no answer about the presence of an individual target. Qualitative identification of local constituents in LMMS spectra can often be obtained by deductive reasoning rather than by fingerprinting. This represents a major advantage in industrial materials science applications, in particular in organic microanalysis because of the numerous structures for each molecular weight. Usually comparison with reference spectra is not even required few reference spectra for organic molecules are available anyway as laser ionisation is a relatively recent development. 

In the past few years, some advances in mass accuracy have made LC-TOF MS a useful tool for molecular identification of unknown compounds. One of the improvements consists in the design of the double sprayer with reference solutions, which corrects the instrument drift by continuous calibration of the mass axis, with an improved mass accuracy to less than 3 ppm. In conclusion, the advantages with respect to LC-MS (SRM) instruments are (a) a large number of targets can be screened at the same time without loss of sensitivity (b) unknown peaks can be identified on the basis of accurate mass and isotopic profile evaluation and, (c) data... 

Nonbenzodiazepine Benzodiazepine Receptor Ligands. The simultaneous discovery of the molecular target for the BZs, the GABA /BZ receptor complex, by two teams of workers (34,35) resulted ia the identification of a number of atypical or anxioselective anxiolytics that, whereas not having the BZ pharmacophore, interacted direcdy with the central BZ receptor. The anxioselective nature of such agents was considered to be... 

The identification of specific nuclear receptors as molecular targets of P450 inducers impacts diug metabolism and diug development in several important ways ... 

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