Targeting index

Hunt et al. [6] also introduced the Drug Targeting Index, which was defined as the ratio of drug delivered to the target and toxicity sites when the drug-carrier conjugate is administered, divided by the same ratio when the active drug is administered intravenously and is formulated as follows. 

Site-Targeting Index and Targeting-Enhancement Factors, 580... 

TEF, as defined here, represents the same ratio as a drug-targeting index used in a theoretical pharmacokinetic treatment (362). 

Stevens, A.J. Martin, S.W. Brennan, B.S. McLachlan, A. Gifford, L.A. Rowland, M. Houston, J.B. Regional drug delivery II Relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation. Pharm.Res., 1995, 12, 1987-1996... 

The recommendations for oilseed rape in the Fertiliser Manual (RB209) are based on yields of 3.5 t/ha of winter OSR and 2 t/ha of spring OSR. To return those nutrients removed from the soil 14 kg of and 11.0 kg of K O should be applied for each toime of seed/ha expected over and above these yields. This only need apply when indices are below the target index of 2 for each element. 

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