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Site-targeting index

Site-Targeting Index and Targeting-Enhancement Factors, 580... [Pg.534]

Hunt et al. [6] also introduced the Drug Targeting Index, which was defined as the ratio of drug delivered to the target and toxicity sites when the drug-carrier conjugate is administered, divided by the same ratio when the active drug is administered intravenously and is formulated as follows. [Pg.358]

Provide a specific interaction between the delivery and biological systems such as site-specific targeting, regional delivery, or localized delivery to improve the therapeutic index of a drug. [Pg.40]

PD studies allow us to understand the potency, effectiveness, therapeutic index, and safety margins of drugs. PK information on ADME provides us with an understanding of how drugs are transported, diffused into the bloodstream, and become available to the cells and act on the target sites. [Pg.171]

See other pages where Site-targeting index is mentioned: [Pg.580]    [Pg.582]    [Pg.580]    [Pg.582]    [Pg.228]    [Pg.511]    [Pg.352]    [Pg.354]    [Pg.356]    [Pg.359]    [Pg.359]    [Pg.360]    [Pg.363]    [Pg.174]    [Pg.42]    [Pg.532]    [Pg.231]    [Pg.529]    [Pg.447]    [Pg.449]    [Pg.451]    [Pg.2]    [Pg.56]    [Pg.153]    [Pg.322]    [Pg.46]    [Pg.121]    [Pg.205]    [Pg.162]    [Pg.64]    [Pg.360]    [Pg.374]    [Pg.137]    [Pg.404]    [Pg.69]    [Pg.267]    [Pg.17]    [Pg.169]    [Pg.170]    [Pg.172]    [Pg.179]    [Pg.243]    [Pg.615]   
See also in sourсe #XX -- [ Pg.2 , Pg.580 ]

See also in sourсe #XX -- [ Pg.580 ]



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Targeting index

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